Disease Sequences High-Accuracy Alignment Based on the Precision Medicine.
High-accuracy alignment of sequences with disease information contributes to disease treatment and prevention. The results of multiple sequence alignment depend on the parameters of the objective function, including gap open penalties (GOP), gap extension penalties (GEP), and substitution matrix (SM...
| Publicado en: | BioMed Research International Vol. 2018; pp. 1 - 10 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2/22/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128130624&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128130624 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2/22/2018 vid: 2018 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 128130624 128130624 128130624 10.1155/2018/1718046 128130624 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Disease Sequences High-Accuracy Alignment Based on the Precision Medicine. aug: au: Li, ManZhi Long, HaiXia Wang, HongTao Fu, HaiYan Xu, Dong Shen, YouJian Yao, YuHua Liao, Bo affil: School of Mathematics and Statistics, Hainan Normal University, Haikou, Hainan 571158, China sug: subj: Sequence Analysis Individualized Medicine Models, Statistical Clinical Assessment Tools Research Instruments Human Disease Management ab: High-accuracy alignment of sequences with disease information contributes to disease treatment and prevention. The results of multiple sequence alignment depend on the parameters of the objective function, including gap open penalties (GOP), gap extension penalties (GEP), and substitution matrix (SM). Firstly, the theory parameter formulas relating to GOP, GAP, and SM are inferred, combining unaligned sequence length, number, and identity. Secondly, we tested the rationality of the theory parameter formulas, with experiment on the ClustalW and MAFFT program. In addition, we obtained a group of MAFFT program parameters according to the formulas proposed. The results of all experiments show that the SPS (sum-of-pair score) obtained from theory parameters is better than the SPS obtained from the default parameters of ClustalW and MAFFT. In both theory and practice, our method to determine the parameters is feasible and efficient. These can provide high-accuracy alignment results for precision medicine. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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