Herzbestrahlung reduziert die mikrovaskuläre Dichte und Akkumulation von HSPA1 in Mäusen.
Purpose: Improvement of radiotherapy techniques reduces the exposure of normal tissues to ionizing radiation. However, the risk of radiation-related late effects remains elevated. In the present study, we investigated long-term effects of radiation on heart muscle morphology.Materials and Methods: W...
| Publicado en: | Strahlentherapie und Onkologie Vol. 194; no. 3; pp. 235 - 243 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128149681&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128149681 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01797158 NZE jtl: Strahlentherapie und Onkologie issn: 01797158 maglogo: N pubinfo: dt: Mar2018 vid: 194 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128149681 128149681 NLM29063166 128149681 10.1007/s00066-017-1220-z NLM29063166 128149681 ppf: 235 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Herzbestrahlung reduziert die mikrovaskuläre Dichte und Akkumulation von HSPA1 in Mäusen. aug: au: Walaszczyk, Anna Szołtysek, Katarzyna Jelonek, Karol Polańska, Joanna Dörr, Wolfgang Haagen, Julia Widłak, Piotr Gabryś, Dorota affil: , Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska–Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland sug: subj: Heart Radiation Effects Blood Vessels Radiation Effects Proteins Metabolism Coronary Vessels Radiation Effects Radiation Injuries Pathology Blood Vessels Pathology Mice Animal Studies Coronary Vessels Pathology Collagen Metabolism Male Dose-Response Relationship, Radiation Cardiotoxicity Pathology Male ab: Purpose: Improvement of radiotherapy techniques reduces the exposure of normal tissues to ionizing radiation. However, the risk of radiation-related late effects remains elevated. In the present study, we investigated long-term effects of radiation on heart muscle morphology.Materials and Methods: We established a mouse model to study microvascular density (MVD), deposition of collagen fibers, and changes in accumulation of heat shock 70 kDa protein 1 (HSPA1) in irradiated heart tissue. Hearts of C57BL/6 mice received a single dose of X‑ray radiation in the range 0.2-16 Gy. Analyses were performed 20, 40, and 60 weeks after irradiation.Results: Reduction in MD was revealed as a long-term effect observed 20-60 weeks after irradiation. Moreover, a significant and dose-dependent increase in accumulation of HSPA1, both cytoplasmic and nuclear, was observed in heart tissues collected 20 weeks after irradiation. We also noticed an increase in collagen deposition in hearts treated with higher doses.Conclusions: This study shows that some changes induced by radiation in the heart tissue, such as reduction in microvessel density, increase in collagen deposition, and accumulation of HSPA1, are observed as long-term effects which might be associated with late radiation cardiotoxicity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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