Olfactory Neuroepithelial Neural Progenitor Cells from Subjects with Bipolar I Disorder.
BACKGROUND: Research into the pathophysiology of bipolar disorder (BD) is limited by the inability to examine brain cellular processes in subjects with the illness. METHODS: Endoscopic biopsy was performed in subjects with bipolar I disorder to establish olfactory neural progenitor (ONP) cell lines....
| Publicado en: | Journal of Central Nervous System Disease no. 9; pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan-Dec2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128158169&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128158169 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795735 B3L8 jtl: Journal of Central Nervous System Disease issn: 11795735 maglogo: Y pubinfo: dt: Jan-Dec2017 iid: 9 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 128158169 128158169 128158169 10.1177/1179573517694529 128158169 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Olfactory Neuroepithelial Neural Progenitor Cells from Subjects with Bipolar I Disorder. aug: au: Yonglin Gao Winstead, Welby Zhenmin Lei Chengliang Lu Roisen, Fred J. El-Mallakh, Rif S. affil: Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY, USA sug: subj: Bipolar Disorder Physiopathology Stem Cells Physiopathology Epithelial Cells Physiopathology Olfaction Disorders Physiopathology Brain Physiopathology Human Smell Biopsy Clinical Assessment Tools Cell Differentiation Outpatients Neurons ab: BACKGROUND: Research into the pathophysiology of bipolar disorder (BD) is limited by the inability to examine brain cellular processes in subjects with the illness. METHODS: Endoscopic biopsy was performed in subjects with bipolar I disorder to establish olfactory neural progenitor (ONP) cell lines. Olfactory function was assessed prebiopsy and postbiopsy using the University of Pennsylvania Smell Identification Test (UPSIT). Cells were characterized to determine their lineage. RESULTS: There were no significant complications associated with the biopsy procedure, including olfaction. Outpatient olfactory neuroepithelial biopsy yielded ONP cells in three out of 13 biopsy attempts (23.1%). ONPs were positive for neuron-specific proteins (β-tubulin III, nestin, hexaribonucleotide binding protein-3, and peripherin) and glia-specific proteins (glial fibrillary acidic protein and myelin basic protein). CONCLUSIONS: ONP cells can be obtained safely from awake outpatients and are potentially useful for pathophysiological studies of bipolar illness and perhaps other neuropsychiatric conditions. Such cells allow for the investigation of potential pathological cellular processes without the confounding factors of genetic manipulation, which is required for induced pluripotent cells. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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