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The curse of angiopoietin-2 in ARDS: on stranger TI(E)des.

Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment.Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregul...

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Published in:Critical Care Vol. 22; pp. 1 - 2
Main Authors: Kümpers, Philipp, Lukasz, Alexander
Format: Journal Article
Published: BioMed Central 2/25/2018
Online Access:View this record in EBSCOhost
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      dt: 2/25/2018
      vid: 22
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      pub: BioMed Central
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        atl: The curse of angiopoietin-2 in ARDS: on stranger TI(E)des.
      aug:
        au:
          Kümpers, Philipp
          Lukasz, Alexander
          Kümpers, Philipp
        affil: Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology University Hospital Münster Albert-Schweitzer-Campus 1 48149 Münster Germany
      sug:
        subj:
          Respiratory Distress Syndrome, Acute Drug Therapy
          Proteins Analysis
          Capillary Permeability Drug Effects
          Proteins Metabolism
          Receptors, Cell Surface Drug Effects
          Transferases Metabolism
          Proteins Blood
          Receptors, Cell Surface Metabolism
          Decision Support Techniques
          Sepsis Prevention and Control
          Sepsis Drug Therapy
          Scales
      ab: Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment.Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins.This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Unknown
    language: English
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