Brief Report: Validation of a Definition of Flare in Patients With Established Gout.
Objective: To perform external validation of a provisional definition of disease flare in patients with gout. Methods: Five hundred nine patients with gout were enrolled in a cross‐sectional study during a routine clinical care visit at 17 international sites. Data were collected to classify patient...
| Publicado en: | Arthritis & Rheumatology Vol. 70; no. 3; pp. 462 - 468 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128210239&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128210239 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23265191 H06R jtl: Arthritis & Rheumatology issn: 23265191 maglogo: N pubinfo: dt: Mar2018 vid: 70 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 128210239 128210239 128210239 10.1002/art.40381 128210239 ppf: 462 ppct: 6 formats: tig: atl: Brief Report: Validation of a Definition of Flare in Patients With Established Gout. aug: au: Gaffo, Angelo L. Dalbeth, Nicola Saag, Kenneth G. Singh, Jasvinder A. Rahn, Elizabeth J. Mudano, Amy S. Chen, Yi‐Hsing Lin, Ching‐Tsai Bourke, Sandra Louthrenoo, Worawit Vazquez‐Mellado, Janitzia Hernández‐Llinas, Hansel Neogi, Tuhina Vargas‐Santos, Ana Beatriz da Rocha Castelar‐Pinheiro, Geraldo Amorim, Rodrigo B. C. Uhlig, Till Hammer, Hilde B. Eliseev, Maxim Perez‐Ruiz, Fernando affil: University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, Alabama sug: subj: Gout Arthritis Cross Sectional Studies Sensitivity and Specificity Predictive Value of Tests ROC Curve Descriptive Statistics Aged Middle Age Human Male Female Validity Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Objective: To perform external validation of a provisional definition of disease flare in patients with gout. Methods: Five hundred nine patients with gout were enrolled in a cross‐sectional study during a routine clinical care visit at 17 international sites. Data were collected to classify patients as experiencing or not experiencing a gout flare, according to a provisional definition. A local expert rheumatologist performed the final independent adjudication of gout flare status. Sensitivity, specificity, predictive values, and receiver operating characteristic (ROC) curves were used to determine the diagnostic performance of gout flare definitions. Results: The mean ± SD age of the patients was 57.5 ± 13.9 years, and 89% were male. The definition requiring fulfillment of at least 3 of 4 criteria (patient‐defined gout flare, pain at rest score of >3 on a 0–10‐point numerical rating scale, presence of at least 1 swollen joint, and presence of at least 1 warm joint) was 85% sensitive and 95% specific in confirming the presence of a gout flare, with an accuracy of 92%. The ROC area under the curve was 0.97. The definition based on a classification and regression tree algorithm (entry point, pain at rest score >3, followed by patient‐defined flare “yes”) was 73% sensitive and 96% specific. Conclusion: The definition of gout flare that requires fulfillment of at least 3 of 4 patient‐reported criteria is now validated to be sensitive, specific, and accurate for gout flares, as demonstrated using an independent large international patient sample. The availability of a validated gout flare definition will improve the ascertainment of an important clinical outcome in studies of gout. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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