Pancreatic cancer screening.
Purpose: This article reviews the current evidence surrounding pancreatic cancer screening. The current targets of screening include identification of early pancreatic cancer, as well as the two most important precursor lesions; intraductal papillary mucinous neoplasm and high grade pancreatic intra...
| Published in: | Abdominal Radiology Vol. 43; no. 2; pp. 264 - 273 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Feb2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128255300&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128255300 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Feb2018 vid: 43 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128255300 10.1007/s00261-017-1308-z 128255300 ppf: 264 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pancreatic cancer screening. aug: au: Lindquist, Chris M. Miller, Frank H. Hammond, Nancy A. Nikolaidis, Paul affil: Department of Radiology, Faculty of Medicine, St. Boniface General Hospital, University of Manitoba, 409 Tache Ave, R2H 2A6, Winnipeg, MB, Canada sug: ab: Purpose: This article reviews the current evidence surrounding pancreatic cancer screening. The current targets of screening include identification of early pancreatic cancer, as well as the two most important precursor lesions; intraductal papillary mucinous neoplasm and high grade pancreatic intraepithelial neoplasia. Given the relatively low incidence of pancreatic adenocarcinoma in the general population, patients with elevated risk based on family history or an underlying genetic syndrome are felt to be the most appropriate patients to undergo screening.Methods: An extensive review of the literature was performed and the major findings of the available literature regarding pancreatic screening are reviewed in detail.Results: Several prospective trials have evaluated pancreatic cancer screening in high-risk groups. The results of those trials are summarized in this article. Current consensus guidelines and recommendations from the International Cancer of the Pancreas Screening Consortium Summit are also discussed.Conclusions: The exact benefit of pancreatic cancer screening remains unclear at this time, but emerging evidence suggests that there is a window of opportunity to detect precursor lesions and early pancreatic adenocarcinomas in high-risk patient populations. Better understanding of the pathway of carcinogenesis will hopefully improve our ability to detect early, resectable pancreatic carcinomas, and provide a mortality benefit to patients at significantly elevated risk of pancreatic adenocarcinoma. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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