Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: A prospective study.
Objectives: To determine whether severity of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis quantitatively assessed in individuals with diabetes mellitus (DM)-2 correlate with increased coronary heart disease (CHD) risk using non-invasive markers.Methods: We conducted a single-centre,...
| Publicado en: | European Radiology Vol. 28; no. 4; pp. 1345 - 1356 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128273226&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128273226 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2018 vid: 28 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128273226 128273226 NLM29058029 128273226 10.1007/s00330-017-5075-6 NLM29058029 128273226 ppf: 1345 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: A prospective study. aug: au: Brouha, Sharon S. Nguyen, Phirum Bettencourt, Ricki Sirlin, Claude B. Loomba, Rohit affil: Department of Radiology, University of California at San Diego, 200 W. Arbor Drive #8756, La Jolla, 92103, San Diego, CA, USA sug: subj: Diabetes Mellitus, Type 2 Complications Nonalcoholic Fatty Liver Disease Complications Liver Cirrhosis Coronary Disease Complications Nonalcoholic Fatty Liver Disease Adipose Tissue Magnetic Resonance Imaging Methods Liver Pathology Diabetes Mellitus, Type 2 Pathology Liver Cirrhosis Pathology Coronary Disease Pathology Cross Sectional Studies Severity of Illness Indices Liver Ultrasonography Pericardium Prospective Studies Liver Cirrhosis Complications Female Middle Age Pericardium Pathology Diabetes Mellitus, Type 2 Adipose Tissue Pathology Nonalcoholic Fatty Liver Disease Pathology Male Funding Source Human Middle Aged: 45-64 years Female Male ab: Objectives: To determine whether severity of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis quantitatively assessed in individuals with diabetes mellitus (DM)-2 correlate with increased coronary heart disease (CHD) risk using non-invasive markers.Methods: We conducted a single-centre, prospective, cross-sectional study in 100 consecutive diabetic individuals without known CHD recruited between March 2013 and September 2014. History, physical examination, serum markers, cardiac computed tomography (CT), magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) and MR elastography (MRE) were obtained for 95 participants. Written informed consent was provided. Institutional review board approved this study. Spearman rank correlation was performed to assess for correlations. Multiple linear regression model determined independent predictors of epicardial adipose tissue (EAT) volume.Results: A p value < 0.05 determined statistical significance. The EAT volume was higher in the NAFLD group, defined as MR-imaging PDFF ≥ 5 %, compared to the non-NAFLD group (126.5 ml (IQR 80.9) versus 85.4 ml (IQR 44.7), p=0.002). MR imaging-PDFF correlated with EAT (r=0.42, p < 0.0001). MR imaging-PDFF and liver fibrosis were independently associated with EAT.Conclusions: Higher liver fat content and liver fibrosis may portend worse cardiovascular risk in diabetics.Key Points: • EAT volume is higher in diabetic individuals with NAFLD. • Liver fat content is positively correlated with EAT. • Liver fat content and liver fibrosis were independently associated with EAT. • Higher liver fat content and fibrosis may adversely affect cardiovascular risk. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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