Sequential designs with small samples: Evaluation and recommendations for normal responses.

Sequential monitoring is a well-known methodology for the design and analysis of clinical trials. Driven by the lower expected sample size, recent guidelines and published research suggest the use of sequential methods for the conduct of clinical trials in rare diseases. However, the vast majority o...

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Detalles Bibliográficos
Publicado en:Statistical Methods in Medical Research Vol. 27; no. 4; pp. 1115 - 1128
Autores principales: Nikolakopoulos, Stavros, Roes, Kit C. B., van der Tweel, Ingeborg, Roes, Kit Cb
Formato: equations & formulas research tables/charts Journal Article
Publicado: Sage Publications Inc. Apr2018
Acceso en línea:Ver este registro en EBSCOhost