Examining alterations in GABA concentrations in the basal ganglia of patients with Parkinson's disease using MEGA-PRESS MRS.
Purpose: The aim of this study was to compare the gamma-amino butyric acid (GABA) levels in the left basal ganglia (BG) of patients with Parkinson's disease (PD) to those of healthy control (HC) volunteers using proton magnetic resonance spectroscopy (1H MRS).Materials and Methods: The GABA+ signal-...
| Publicado en: | Japanese Journal of Radiology Vol. 36; no. 3; pp. 194 - 200 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128302123&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128302123 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Mar2018 vid: 36 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128302123 128302123 144093408 NLM29280067 128302123 10.1007/s11604-017-0714-z NLM29280067 128302123 ppf: 194 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Examining alterations in GABA concentrations in the basal ganglia of patients with Parkinson's disease using MEGA-PRESS MRS. aug: au: Elmaki, Elsadig E. A. Tao Gong Nkonika, D. Menene Guangbin Wang Gong, Tao Wang, Guangbin affil: Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Shandong University, No. 324, Jingwu Road, Jinan 250021, People's Republic of China sug: subj: Basal Ganglia Metabolism Basal Ganglia GABA Metabolism Parkinson Disease Metabolism Image Processing, Computer Assisted Methods Proton Magnetic Resonance Spectroscopy Methods Aged Middle Age Male Female Human Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Purpose: The aim of this study was to compare the gamma-amino butyric acid (GABA) levels in the left basal ganglia (BG) of patients with Parkinson's disease (PD) to those of healthy control (HC) volunteers using proton magnetic resonance spectroscopy (1H MRS).Materials and Methods: The GABA+ signal-the composite signal from GABA, macromolecules (MMs), and homocarnosine-was detected. GABA+ levels were examined in 21 PD patients and 15 age- and sex-matched HCs. 3T-1H-MRS using the Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) sequence was performed in order to detect GABA+ levels in the left BG, and the spectra were processed using the Gannet software. Differences in GABA+ levels between the two groups were analyzed using independent t-test analysis.Results: The GABA+ levels were significantly lower (P < 0.001) in the left BG of the patients with PD (1.31 ± 0.21 i.u.) than in the left BG of the HCs (1.62 ± 0.26 i.u.).Conclusion: The lower GABA+ levels in the left BG of the PD patients suggest that GABA plays an important role in the pathogenesis of PD. The reduced GABA+ levels in the PD patients may be associated with GABAergic dysfunction. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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