l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation.
Purpose: The aim of this trial was to investigate the influence of a dietetic product consisting of a unique combination of l-arginine with the vitamins B6, folic acid and B12 (Telcor® Arginin plus) on endothelial dysfunction.Methods: Subjects aged 40-65 years with mild to moderate blood pressure (B...
| Publicado en: | European Journal of Nutrition Vol. 57; no. 2; pp. 557 - 569 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128420791&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128420791 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2018 vid: 57 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128420791 128420791 128420791 10.1007/s00394-016-1342-6 128420791 ppf: 557 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: l-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation. aug: au: Menzel, Daniel Haller, Hermann Wilhelm, Manfred Robenek, Horst affil: Stuttgart, Germany sug: subj: Arginine Pharmacodynamics Vitamin B12 Pharmacodynamics Folic Acid Pharmacodynamics Pyridoxine Pharmacodynamics Epithelial Cells Drug Effects Blood Pressure Drug Effects Dietetics Hypertension Prevention and Control Human Middle Age Adult After Care Homocysteine Blood Arginine Therapeutic Use Vitamin B12 Therapeutic Use Folic Acid Therapeutic Use Pyridoxine Therapeutic Use Drug Combinations Middle Aged: 45-64 years Adult: 19-44 years ab: Purpose: The aim of this trial was to investigate the influence of a dietetic product consisting of a unique combination of l-arginine with the vitamins B6, folic acid and B12 (Telcor® Arginin plus) on endothelial dysfunction.Methods: Subjects aged 40-65 years with mild to moderate blood pressure (BP) elevation not treated with anti-hypertensive drugs were randomly assigned to either the dietetic product (<italic>n</italic> = 40) or a matching placebo (<italic>n</italic> = 41) for 3 months with open follow-up for a further 3 months. Postprandial change in endothelial function was assessed using the validated reactive hyperaemia index (RHI) at 3 months compared to the study onset (RHI post-pre, visit 3-visit 1; ΔΔRHI). Secondary parameters included BP and plasma homocysteine concentration.Results: The primary efficacy analysis revealed superiority of the nutritional intervention over placebo (<italic>p</italic> = 0.0349) in reducing the deterioration of endothelial function. While in the active group ΔΔRHI increased (0.371 ± 0.122), almost no change could be detected in the placebo group (0.031 ± 0.100), thus demonstrating a significant improvement in vascular function in the intervention group. Moreover, the intervention reduced BP and homocysteine levels. Non-serious adverse events were equally distributed in both groups, and none of the events were assessed as possibly intervention-related by the investigators.Conclusions: This trial confirmed the effective and safe use of dietary management with l-arginine in combination with B vitamins. The primary efficacy analysis demonstrated a statistically significant superiority of the combination of l-arginine with B vitamins over placebo in improving and restoring impaired endothelial function and lowering BP in patients with mild to moderate blood pressure elevation. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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