Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats.
Purpose: Zinc restriction during fetal and postnatal development could program cardiovascular diseases in adulthood. The aim of this study was to determine the effects of zinc restriction during fetal life, lactation, and/or post-weaning growth on cardiac inflammation, apoptosis, oxidative stress, a...
| Published in: | European Journal of Nutrition Vol. 57; no. 2; pp. 569 - 584 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Mar2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128420792&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128420792 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2018 vid: 57 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128420792 128420792 128420792 10.1007/s00394-016-1343-5 128420792 ppf: 569 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats. aug: au: Juriol, Lorena Vanesa Gobetto, María Natalia Mendes Garrido Abregú, Facundo Dasso, Marina Ercilia Pineda, Gonzalo Güttlein, Leandro Carranza, Andrea Podhajcer, Osvaldo Toblli, Jorge Eduardo Elesgaray, Rosana Arranz, Cristina Teresa Tomat, Analía Lorena affil: Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA). Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, 956, piso 7, 1113, Junín, Ciudad Autónoma de Buenos Aires, Argentina sug: subj: Zinc Deficiency Apoptosis Inflammation Oxidative Stress Nitric Oxide Synthases Lactation Infant Weaning Fetal Development Gene Expression Myocytes, Cardiac Animal Studies Rats Interleukins Tumor Necrosis Factor Biological Assay Cardiovascular Diseases RNA, Messenger Signal Transduction Zinc Therapeutic Use Diet Adverse Effects Indicators and Reagents Nucleotides Phosphorylation Heart Ventricle, Left Physiology ab: Purpose: Zinc restriction during fetal and postnatal development could program cardiovascular diseases in adulthood. The aim of this study was to determine the effects of zinc restriction during fetal life, lactation, and/or post-weaning growth on cardiac inflammation, apoptosis, oxidative stress, and nitric oxide system of male and female adult rats.Methods: Wistar rats were fed a low- or a control zinc diet during pregnancy and up to weaning. Afterward, offspring were fed either a low- or a control zinc diet until 81 days of life. IL-6 and TNF-α levels, TUNEL assay, TGF-β1 expression, thiobarbituric acid-reactive substances that determine lipoperoxidation damage, NADPH oxidase-dependent superoxide anion production, antioxidant and nitric oxide synthase activity, mRNA and protein expression of endothelial nitric oxide synthase, and serine1177 phosphorylation isoform were determined in left ventricle.Results: Zinc deficiency activated apoptotic and inflammatory processes and decreased TGF-β1 expression and nitric oxide synthase activity in cardiac tissue of both sexes. Male zinc-deficient rats showed no changes in endothelial nitric oxide synthase expression, but a lower serine1177 phosphorylation. Zinc deficiency induced an increase in antioxidant enzymes activity and no differences in lipoperoxidation products levels in males. Females were less sensitive to this deficiency exhibiting lower increase in apoptosis, lower decrease in expression of TGF-β1, and higher antioxidant and nitric oxide enzymes activities. A zinc-adequate diet during postnatal life reversed most of these mechanisms.Conclusion: Prenatal and postnatal zinc deficiency induces alterations in cardiac apoptotic, inflammatory, oxidative, and nitric oxide pathways that could predispose the onset of cardiovascular diseases in adult life. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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