Usefulness of perfusion- and diffusion-weighted imaging to differentiate between pilocytic astrocytomas and high-grade gliomas: a multicenter study in Japan.
Purpose: Imaging findings of pilocytic astrocytoma (PA) vary widely, sometimes resembling those of high-grade glioma (HGG). This study aimed to identify the imaging parameters that can be used to differentiate PA from HGG.Methods: Altogether, 60 patients with PAs and 138 patients with HGGs were incl...
| Publicado en: | Neuroradiology Vol. 60; no. 4; pp. 391 - 402 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128532446&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128532446 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Apr2018 vid: 60 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128532446 128532446 128532446 10.1007/s00234-018-1991-7 128532446 ppf: 391 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Usefulness of perfusion- and diffusion-weighted imaging to differentiate between pilocytic astrocytomas and high-grade gliomas: a multicenter study in Japan. aug: au: Kikuchi, Kazufumi Hiwatashi, Akio Togao, Osamu Yamashita, Koji Kamei, Ryotaro Kitajima, Mika Kanoto, Masafumi Takahashi, Hiroto Uchiyama, Yusuke Harada, Masafumi Shinohara, Yuki Yoshiura, Takashi Wakata, Yuki Honda, Hiroshi affil: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan sug: subj: Glioma Diagnosis Perfusion Imaging Methods Magnetic Resonance Imaging Methods Neoplasm Grading Sensitivity and Specificity Japan Human Multicenter Studies Hydrocephalus Cerebral Edema Cerebrovascular Circulation Cerebral Blood Volume Mann-Whitney U Test ROC Curve Contrast Media Diagnostic Use Glioma Pathology ab: Purpose: Imaging findings of pilocytic astrocytoma (PA) vary widely, sometimes resembling those of high-grade glioma (HGG). This study aimed to identify the imaging parameters that can be used to differentiate PA from HGG.Methods: Altogether, 60 patients with PAs and 138 patients with HGGs were included in the study. Tumor properties and the presence of hydrocephalus, peritumoral edema, and dissemination were evaluated. We also measured the maximum relative cerebral blood flow (rCBFmax) and volume (rCBVmax) and determined the minimum apparent diffusion coefficient (ADCmin) in the tumor’s solid components. The relative T1 (rT1), T2 (rT2), and contrast-enhanced T1 (rCE-T1) intensity values were evaluated. Parameters were compared between PAs and HGGs using the Mann-Whitney <italic>U</italic> test. Receiver operating characteristic (ROC) curve analysis was also used to evaluate these imaging parameters. A value of <italic>P</italic> < .05 was considered to indicate significance.Results: Intratumoral hemorrhage and calcification were observed in 10.0% and 21.7% of PAs, respectively. The rCBFmax and rCBVmax values were significantly lower in PAs (0.50 ± 0.35, 1.82 ± 1.21) than those in HGGs (2.98 ± 1.80, 9.54 ± 6.88) (<italic>P</italic> < .0001, <italic>P</italic> = .0002, respectively). The ADCmin values were significantly higher in PAs (1.36 ± 0.56 × 10−3 mm2/s) than those in HGGs (0.86 ± 0.37 × 10−3 mm2/s) (<italic>P</italic> < .0001). ROC analysis showed that the best diagnostic performance was achieved with rCBFmax.Conclusion: The rCBFmax, rCBVmax, and ADCmin can differentiate PAs from HGGs. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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