New Understanding of β-Cell Heterogeneity and In Situ Islet Function.
Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific su...
| Publicado en: | Diabetes Vol. 67; no. 4; pp. 537 - 548 |
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| Autores principales: | , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
American Diabetes Association
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128597030&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128597030 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121797 1G6 jtl: Diabetes issn: 00121797 maglogo: N pubinfo: dt: Apr2018 vid: 67 iid: 4 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 128597030 128597030 NLM29559510 128597030 10.2337/dbi17-0040 NLM29559510 128597030 ppf: 537 ppct: 11 formats: tig: atl: New Understanding of β-Cell Heterogeneity and In Situ Islet Function. aug: au: Benninger, Richard K. P. Hodson, David J. affil: Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO sug: subj: Cell Physiology Islets of Langerhans Cell Differentiation Islets of Langerhans Metabolism Cell Membrane Metabolism Genetic Techniques Cytological Techniques Cell Communication Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Funding Source ab: Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity. This includes specific subpopulations with distinct functional characteristics, developmental programs, abilities to proliferate in response to metabolic or developmental cues, and resistance to immune-mediated damage. Importantly, these subpopulations change in disease or aging, including in human disease. Although discovering new β-cell subpopulations has substantially advanced our understanding of islet biology, a point of caution is that these characteristics have often necessarily been identified in single β-cells dissociated from the islet. β-Cells in the islet show extensive communication with each other via gap junctions and with other cell types via diffusible chemical messengers. As such, how these different subpopulations contribute to in situ islet function, including during plasticity, is not well understood. We will discuss recent findings revealing functional β-cell subpopulations in the intact islet, the underlying basis for these identified subpopulations, and how these subpopulations may influence in situ islet function. Furthermore, we will discuss the outlook for emerging technologies to gain further insight into the role of subpopulations in in situ islet function. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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