Glucose as a stimulation agent in the BOLD functional magnetic resonance imaging for liver cirrhosis and hepatocellular carcinoma: a feasibility study.
Purpose: To explore the role of glucose as a stimulation agent in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) for liver cirrhosis and hepatocellular carcinoma (HCC).Materials and Methods: Twenty HCC patients with cirrhosis and 10 healthy volunteers were recru...
| Publicado en: | Abdominal Radiology Vol. 43; no. 3; pp. 607 - 613 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128598141&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128598141 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Mar2018 vid: 43 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128598141 10.1007/s00261-017-1264-7 128598141 ppf: 607 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Glucose as a stimulation agent in the BOLD functional magnetic resonance imaging for liver cirrhosis and hepatocellular carcinoma: a feasibility study. aug: au: Yuan, Fang Song, Bin Huang, Zixing Liu, Xijiao Xia, Chunchao affil: Department of Radiology, West China Hospital of Sichuan University, Chengdu, China sug: ab: Purpose: To explore the role of glucose as a stimulation agent in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) for liver cirrhosis and hepatocellular carcinoma (HCC).Materials and Methods: Twenty HCC patients with cirrhosis and 10 healthy volunteers were recruited. BOLD fMRI was performed for all participants prior to and 30 min after oral administration of glucose to measure the T2* values of normal liver parenchyma, HCC liver parenchyma, HCC center, and HCC edge. Variations of the T2*(△T2*) before and after administration were calculated.Results: Data from 16 patients and 10 healthy volunteers were reported. Before and after oral administration of glucose, T2* values of the normal liver parenchyma, HCC liver parenchyma, and HCC center were statistically different (<italic>p</italic> < 0.01), while no statistical difference was found in T2* value of the HCC edge (<italic>p</italic> = 0.35). △T2* values of the normal liver parenchyma, HCC liver parenchyma, HCC center, and HCC edge were 2.8 ± 1.1 ms, −1.3 ± 1.2 ms, −2.1 ± 1.8 ms, and 0.8 ± 3.2 ms before and after administration, respectively. △T2* value was statistically different in the liver parenchyma between healthy volunteers and HCC patients and between HCC center and HCC edge (both <italic>p</italic> < 0.01).Conclusion: Use of glucose as the stimulation agent in BOLD fMRI may facilitate the assessment of liver function for patients with liver cirrhosis. The potential of △T2* to correlate with severity of liver cirrhosis, as well as to evaluate hepatic artery perfusion and bioactivity of HCC center should be further investigated. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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