A New Measure for Neural Compensation Is Positively Correlated With Working Memory and Gait Speed.
Neuroimaging studies suggest that older adults may compensate for declines in brain function and cognition through reorganization of neural resources. A limitation of prior research is reliance on between-group comparisons of neural activation (e.g., younger vs. older), which cannot be used to asses...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 11 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Frontiers Media S.A.
3/19/2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128600329&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128600329 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 3/19/2018 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 128600329 10.3389/fnagi.2018.00071 128600329 ppf: 1 ppct: 10 formats: tig: atl: A New Measure for Neural Compensation Is Positively Correlated With Working Memory and Gait Speed. aug: au: Ji, Lanxin Pearlson, Godfrey D. Hawkins, Keith A. Steffens, David C. Guo, Hua Wang, Lihong affil: Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China sug: ab: Neuroimaging studies suggest that older adults may compensate for declines in brain function and cognition through reorganization of neural resources. A limitation of prior research is reliance on between-group comparisons of neural activation (e.g., younger vs. older), which cannot be used to assess compensatory ability quantitatively. It is also unclear about the relationship between compensatory ability with cognitive function or how other factors such as physical exercise modulates compensatory ability. Here, we proposed a data-driven method to semi-quantitatively measure neural compensation under a challenging cognitive task, and we then explored connections between neural compensation to cognitive engagement and cognitive reserve (CR). Functional and structural magnetic resonance imaging scans were acquired for 26 healthy older adults during a face-name memory task. Spatial independent component analysis (ICA) identified visual, attentional and left executive as core networks. Results show that the smaller the volumes of the gray matter (GM) structures within core networks, the more networks were needed to conduct the task (r =-0.408, p = 0.035). Therefore, the number of task-activated networks controlling for the GM volume within core networks was defined as a measure of neural compensatory ability. We found that compensatory ability correlated with working memory performance (r = 0.528, p = 0.035). Among subjects with good memory task performance, those with higher CR used fewer networks than subjects with lower CR. Among poor-performance subjects, those using more networks had higher CR. Our results indicated that using a high cognitivedemanding task to measure the number of activated neural networks could be a useful and sensitive measure of neural compensation in older adults. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|