Lack of Benefit of Heliox During Mechanical Ventilation of Subjects With Severe Air-Flow Obstruction.
BACKGROUND: The value of heliox (helium-oxygen mixture) for patients with severe air-flow obstruction is uncertain. The purpose of this study was to determine whether heliox could reduce the degree of hyperinflation and hypercapnia in mechanically ventilated patients with severe airflow obstruction....
| Publicado en: | Respiratory Care Vol. 63; no. 4; pp. 375 - 380 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128622752&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128622752 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Apr2018 vid: 63 iid: 4 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 128622752 128622752 128622752 10.4187/respcare.05893 128622752 ppf: 375 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Lack of Benefit of Heliox During Mechanical Ventilation of Subjects With Severe Air-Flow Obstruction. aug: au: Leatherman, James W. Saavedra Romero, Ramiro Shapiro, Robert S. affil: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota sug: subj: Respiratory Airflow Helium Oxygen Respiration, Artificial Evaluation Lung Diseases Diagnosis Prospective Studies Intensive Care Units Academic Medical Centers Blood Gas Analysis Positive End-Expiratory Pressure Data Analysis Software Pulmonary Disease, Chronic Obstructive Diagnosis Descriptive Statistics ab: BACKGROUND: The value of heliox (helium-oxygen mixture) for patients with severe air-flow obstruction is uncertain. The purpose of this study was to determine whether heliox could reduce the degree of hyperinflation and hypercapnia in mechanically ventilated patients with severe airflow obstruction. METHODS: This was a single-center, prospective observational study conducted in a medical ICU of an academic medical center. We assessed the impact of heliox (65-70% helium, 30-35% oxygen) on airway pressures and arterial blood gases of 13 subjects undergoing mechanical ventilation for severe asthma (n = 8) or exacerbation of COPD (n = 5). RESULTS: As compared with ventilation with air-O2, heliox resulted in a reduction in peak airway pressure (54.1 ± 12.6 cm H2O vs 47.9 ± 10.8 cm H2O, P < .001) and PaCO2 (64.3 ± 14.9 mm Hg vs 62.3 ± 15.1mmHg, P = .01). In contrast, there was no change in plateau pressure (25.3±5.5 cm H2O vs 25.8 ± 5.6 cm H2O, P = .14) or total PEEP (13.4 ± 3.8 cm H2O vs 13.3 ± 4.1 cm H2O, P = .79) in response to heliox. CONCLUSIONS: In mechanically ventilated subjects with severe air-flow obstruction, administration of heliox had no effect on indices of dynamic hyperinflation (plateau pressure and total PEEP) and resulted in only a small reduction in PaCO2. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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