Inhalation Sedation in Subjects With ARDS Undergoing Continuous Lateral Rotational Therapy.
INTRODUCTION: Isoflurane has shown better sedation control and potential benefits in patients with ARDS compared to propofol or midazolam, but the practical use during continuous lateral rotational therapy remains unknown. We therefore compared isoflurane with propofol and midazolam regarding sedati...
| Publicado en: | Respiratory Care Vol. 63; no. 4; pp. 441 - 448 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128622761&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128622761 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Apr2018 vid: 63 iid: 4 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 128622761 128622761 128622761 10.4187/respcare.05751 128622761 ppf: 441 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Inhalation Sedation in Subjects With ARDS Undergoing Continuous Lateral Rotational Therapy. aug: au: Meiser, Andreas Groesdonk, Heinrich V. Bonnekessel, Sarah Volk, Thomas Bomberg, Hagen affil: Department of Anesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University Medical Center, Homburg/Saar, Germany sug: subj: Respiratory Distress Syndrome, Acute Therapy Sedation Methods Administration, Inhalation Patient Care Human Technology, Medical Isoflurane Administration and Dosage Propofol Midazolam Drug Evaluation Analgesics, Opioid Administration and Dosage Respiration Physiology Intensive Care Units Respiratory Distress Syndrome, Acute Physiopathology Male Female Middle Age Data Analysis Software Descriptive Statistics Middle Aged: 45-64 years Male Female ab: INTRODUCTION: Isoflurane has shown better sedation control and potential benefits in patients with ARDS compared to propofol or midazolam, but the practical use during continuous lateral rotational therapy remains unknown. We therefore compared isoflurane with propofol and midazolam regarding sedation depth (per the Richmond Agitation-Sedation Scale), opioid consumption, lung function, and hemodynamics in patients treated with continuous lateral rotational therapy. METHODS: 38 consecutive critically ill surgical subjects were retrospectively studied using a hospital database. All subjects suffered from ARDS and were treated with continuous lateral rotational therapy between May 2010 and September 2013. Nineteen subjects were sedated with propofol or midazolam and compared with 19 subjects sedated with isoflurane using the AnaConDa-system. RESULTS: Isoflurane sedation resulted in significantly lower Richmond Agitation-Sedation Scale scores compared with propofol or midazolam. Despite deep isoflurane sedation, opioid consumption could be significantly reduced. Spontaneous breathing was possible in 90% of the subjects on isoflurane sedation compared with 16% of the subjects sedated with propofol or midazolam. The difference between peak inspiratory pressure and PEEP was significantly decreased after 24 h of isoflurane sedation. Oxygenation (PaO2/FIO2) improved in both groups. Hemodynamics and need for vasopressor therapy were comparable between groups. CONCLUSIONS: This study supports the feasibility of isoflurane sedation using continuous lateral rotational therapy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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