Optical assessment of the in vivo tympanic membrane status using a handheld optical coherence tomography-based otoscope.
Objective: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We des...
| Publicado en: | Acta Oto-Laryngologica Vol. 138; no. 4; pp. 367 - 375 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Objective: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We designed this study to examine the TMs with middle ear diseases using a handheld otoscope employing 860nm spectral domain (SD)-OCT, combined with video camera and to demonstrate the clinical applicability of this system. Design: A total of 120 patients with otologic symptoms were enrolled. TM images were obtained using the handheld OCT-based otoscope (860nm central wave length, 15 lm axial resolution, 15 lm lateral resolution, and 7mm scanning range using relay lens). Both OCT and oto-endoscope images were compared according to the clinical characteristics such as perforation, retraction, and postoperative healing process. Results: The objective grade about the thickness of perforation margins and the accurate information about the extent of TM retraction that was not distinguishable by oto-endoscopic exam could be identified using this system. The postoperative healing process of TMs could be also followed using the OCT device. Conclusion: These analyses from the surgeon-oriented perspective suggest another useful application of the handheld OCT device. 目的：用于检查鼓膜（TM）的常规耳镜和耳内窥镜不能提供断层信息。光学相干断层扫描（OCT）非侵入性地揭示了具有高度空间分辨率的TM的深度分辨的内部微结构。我们设计了这项研究, 使用860 nm光谱域（SD）-OCT的手持式耳镜, 结合使用摄像机, 来检查带有中耳病的TM, 并展示该系统的临床适用性。 设计：共纳入120例耳蜗症状患者。使用手持式OCT耳镜（860nm中心波长, 15μm轴向分辨率, 15μm横向分辨率和使用中继透镜的7mm扫描范围）获得TM图像。根据临床特征（如穿孔、收缩和术后愈合过程）来比较OCT和耳镜内窥镜图像。 结果：使用该系统可以确定穿孔边缘厚度的目标等级以及用耳内窥镜检查无法区分的TM收缩程度的准确信息。使用OCT装置也可以跟踪TM的术后愈合过程。 结论：从外科医生角度来看, 这些分析表明手持式OCT装置具有另一个有用的应用。 |
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