Image-Based Structural Modeling of the Cardiac Purkinje Network.
The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significan...
| Publicado en: | BioMed Research International Vol. 2015; pp. 1 - 16 |
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| Autores principales: | , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
10/25/2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128652182&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128652182 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/25/2015 vid: 2015 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 128652182 128652182 128652182 10.1155/2015/621034 128652182 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Image-Based Structural Modeling of the Cardiac Purkinje Network. aug: au: Liu, Benjamin R. Cherry, Elizabeth M. affil: School of Mathematical Sciences, Rochester Institute of Technology, Rochester, NY 14623, USA sug: subj: Purkinje Fibers Models, Biological Imaging, Three-Dimensional Digital Imaging Human Dissection Heart Ventricle Surgery Endocardium Arrhythmia, Ventricular ab: The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the genesis and maintenance of ventricular arrhythmias. Despite its importance, few structuralmodels of the Purkinje network have been developed, primarily because current physical limitations prevent examination of the intact Purkinje network. In previousmodeling efforts Purkinje-like structures have been developed through either automated or hand-drawn procedures, but these networks have been created according to general principles rather than based on real networks. To allow for greater realism in Purkinje structural models, we present a method for creating three-dimensional Purkinje networks based directly on imaging data. Our approach uses Purkinje network structures extracted fromphotographs of dissected ventricles and projects these flat networks onto realistic endocardial surfaces.Using this method,we createmodels for the combined ventricle-Purkinje system that can fully activate the ventricles through a stimulus delivered to the Purkinje network and can produce simulated activation sequences that match experimental observations. The combined models have the potential to help elucidate Purkinje network contributions during ventricular arrhythmias. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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