Earlier alcohol use onset prospectively predicts changes in functional connectivity.
Background Half of all new alcohol initiates are between 12 and 17 years old. This is a period of intense neurodevelopment, including changes in functional connectivity patterns among higher-order function areas. It is crucial to understand how alcoholrelated neurotoxicity may be influenced by drink...
| Publicado en: | Psychopharmacology Vol. 235; no. 4; pp. 1041 - 1055 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128698410&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128698410 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Apr2018 vid: 235 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128698410 10.1007/s00213-017-4821-4 128698410 ppf: 1041 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Earlier alcohol use onset prospectively predicts changes in functional connectivity. aug: au: Nguyen-Louie, Tam T. Simmons, Alan N. Squeglia, Lindsay M. Infante, M. Alejandra Schacht, Joseph P. Tapert, Susan F. affil: San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA sug: ab: Background Half of all new alcohol initiates are between 12 and 17 years old. This is a period of intense neurodevelopment, including changes in functional connectivity patterns among higher-order function areas. It is crucial to understand how alcoholrelated neurotoxicity may be influenced by drinking onset age. Design This study prospectively examined the effects of age of first drink on frontoparietal context-dependent functional connectivity (cdFC) during a visual working memory task. Youth 13.5 years of age (SD = 1.2) underwent a neuropsychological and neuroimaging session before drinking initiation and at follow-up 6 years later. Hierarchical linear regressions examined if youth with earlier ages of onset for first and weekly alcohol use showed higher follow-up cdFC between the dorsolateral prefrontal cortex and posterior parietal cortex regions of interest and whole-brain exploratory regions, controlling for predrinking cdFC. Higher follow-up cdFC was hypothesized to be correlated with poorer performances in neuropsychological performance. Results Exploratory whole-brain analyses showed that, as hypothesized, earlier ages of weekly drinking onset were associated with higher cdFC between the bilateral posterior cingulate and cortical and subcortical areas implicated in attentional processes, which was in turn associated with poorer performance on neuropsychological tasks of attention, ps < .05. No relationship between age of onset and cdFC between the two ROIs were found. Conclusion Earlier ages of weekly alcohol use initiation may adversely affect neurodevelopment by reducing developmentally appropriate integration of attentional circuits during a cognitive challenge. Delaying the onset of weekly alcohol use patterns well after early adolescence may reduce the risk for harm of alcohol use on the brain. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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