Development of a Computer-Aided Differential Diagnosis System to Distinguish Between Usual Interstitial Pneumonia and Non-specific Interstitial Pneumonia Using Texture- and Shape-Based Hierarchical Classifiers on HRCT Images.

A computer-aided differential diagnosis (CADD) system that distinguishes between usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) using high-resolution computed tomography (HRCT) images was developed, and its results compared against the decision of a radiologist. Si...

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Publicado en:Journal of Digital Imaging Vol. 31; no. 2; pp. 235 - 245
Autores principales: Sang Hoon Jun, Beom Hee Park, Joon Beom Seo, Sang Min Lee, Namkug Kim
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Apr2018
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2018
      vid: 31
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-017-0018-y
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        atl: Development of a Computer-Aided Differential Diagnosis System to Distinguish Between Usual Interstitial Pneumonia and Non-specific Interstitial Pneumonia Using Texture- and Shape-Based Hierarchical Classifiers on HRCT Images.
      aug:
        au:
          Sang Hoon Jun
          Beom Hee Park
          Joon Beom Seo
          Sang Min Lee
          Namkug Kim
        affil: Biomedical Engineering Research Center, Asan Institute of Life Science, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap2-dong, Songpa-gu, Seoul, Republic of Korea
      sug:
        subj:
          Lung Diseases
          Diagnosis, Computer Assisted
          Diagnosis, Differential
          Idiopathic Interstitial Pneumonias Diagnosis
          Tomography, X-Ray Computed Methods
          Human
          Lung Diseases, Interstitial
          Machine Learning
          Lung Radiography
          Tomography, X-Ray Computed Utilization
          Pulmonologists
          Validity
          Radiologists
          Decision Making, Clinical
      ab: A computer-aided differential diagnosis (CADD) system that distinguishes between usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) using high-resolution computed tomography (HRCT) images was developed, and its results compared against the decision of a radiologist. Six local interstitial lung disease patterns in the images were determined, and 900 typical regions of interest were marked by an experienced radiologist. A support vector machine classifier was used to train and label the regions of interest of the lung parenchyma based on the texture and shape characteristics. Based on the regional classifications of the entire lung using HRCT, the distributions and extents of the six regional patterns were characterized through their CADD features. The disease division index of every area fraction combination and the asymmetric index between the left and right lungs were also evaluated. A second SVM classifier was employed to classify the UIP and NSIP, and features were selected through sequential-forward floating feature selection. For the evaluation, 54 HRCT images of UIP (n = 26) and NSIP (n = 28) patients clinically diagnosed by a pulmonologist were included and evaluated. The classification accuracy was measured based on a fivefold crossvalidation with 20 repetitions using random shuffling. For comparison, thoracic radiologists assessed each case using HRCT images without clinical information or diagnosis. The accuracies of the radiologists' decisions were 75 and 87%. The accuracies of the CADD system using different features ranged from 70 to 81%. Finally, the accuracy of the proposed CADD system after sequential-forward feature selection was 91%.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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