Endogenous markers for kidney function in children: a review.
Although glomerular filtration rate (GFR) in children can be measured using a gold-standard technique following injection of an exogenous marker, this invasive and cumbersome technique is not widely available and GFR is commonly estimated using serum levels of endogenous markers. Creatinine, urea, c...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 55; no. 3; pp. 163 - 184 |
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| Autores principales: | , , |
| Formato: | equations & formulas review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128734120&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128734120 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: May2018 vid: 55 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 128734120 128734120 128734120 10.1080/10408363.2018.1427041 128734120 ppf: 163 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Endogenous markers for kidney function in children: a review. aug: au: den Bakker, Emil Gemke, Reinoud J. B. J. Bökenkamp, Arend affil: Department of Pediatric Nephrology, VU Medical Centre, Amsterdam, The Netherlands sug: subj: Kidney Physiology Biological Markers Child Glomerular Filtration Rate Creatinine Blood Urea Blood Cystatin C Blood Serum Globulins Blood Diet Child: 6-12 years ab: Although glomerular filtration rate (GFR) in children can be measured using a gold-standard technique following injection of an exogenous marker, this invasive and cumbersome technique is not widely available and GFR is commonly estimated using serum levels of endogenous markers. Creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin are well-established endogenous markers of kidney function. These markers differ in site of production and effects of diet and medication, as well as renal-tubular handling and extra-renal elimination. For each marker, different methods are available for measurement. Importantly, the measurements of creatinine and cystatin C have recently been standardized with the introduction of international reference standards. In order to allow estimation of GFR from serum marker concentrations, different equations for estimated GFR (eGFR) have been developed in children, using simple or more complex regression strategies with gold standard GFR measurements as a dependent variable. As a rule, estimation strategies relying on more than one marker - either by calculating the average of single parameter equations or by using more complex equations incorporating several parameters - outperform eGFR estimations using only a single marker. This in-depth review will discuss the physiology, measurement and clinical use of creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin in children. It will also address the generation of eGFR equations in children and provide an overview of currently available eGFR equations for the pediatric age group. pubtype: Academic Journal doctype: equations & formulas review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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