Complex antioxidants in a randomized single-blinded study of memory in seniors.
Introduction: Oxidative injury to the brain and aging are theoretical co-causes of Alzheimer’s Disease (AD). Amyloid plaques and tangles are then secondary phenomenon. The preclinical state would then be ‘normal’ elderly.Methods: A potent complex antioxidant (antiOx) was tested against a popular one...
| Publicado en: | Aging Clinical & Experimental Research Vol. 30; no. 4; pp. 395 - 406 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128815043&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128815043 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15940667 2WMP jtl: Aging Clinical & Experimental Research issn: 15940667 maglogo: N pubinfo: dt: Apr2018 vid: 30 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128815043 128815043 128815043 10.1007/s40520-017-0788-6 128815043 ppf: 395 ppct: 11 formats: tig: atl: Complex antioxidants in a randomized single-blinded study of memory in seniors. aug: au: Summers, William K. Martin, Roy L. Liu, Yimeng Peña, Bernice Marsh, Gary M. affil: Alzheimer’s Corporation, 6000 Uptown Blvd, Suite 308, 87110, Albuquerque, NM, USA sug: subj: Memory Drug Effects Vitamins Pharmacodynamics Dietary Supplementation Human Randomized Controlled Trials Vitamins Time Factors Memory, Short Term Cell Differentiation Alzheimer's Disease Drug Therapy Community Living Oxidative Stress Drug Effects Aged Aged: 65+ years ab: Introduction: Oxidative injury to the brain and aging are theoretical co-causes of Alzheimer’s Disease (AD). Amyloid plaques and tangles are then secondary phenomenon. The preclinical state would then be ‘normal’ elderly.Methods: A potent complex antioxidant (antiOx) was tested against a popular one-a-day multivitamin (mV) in a randomized single blind design in ‘normal’ senior subjects over 6 months. Memory testing was done at baseline, 1, 3, and 6 months. The generalized estimating equation (GEE) approach was used to compare the change score of NLT100 and 20WR between two groups over time.Results: Analysis of the antiOx group (30 subjects) demonstrated significant improvement in declarative memory (change score for NLT100 at month 6 = 6.36 <italic>p</italic> < 0.0001) and working memory (change score for 20WR at month 6 = 3.23, <italic>p</italic> < 0.0001). A change-score analysis over 6 months suggests possible neurogenesis in the antiOx group. The mV group (33 subjects) had a change score of the NLT100 and 20WR on the sixth month of 2.20 and 0.32 (<italic>p</italic> = 0.07, 0.35).Conclusions: A complex antioxidant blend, sold as an over-the-counter (OTC) supplement, can improve memory in elder subjects. Antioxidants may be beneficial in AD and other neurodegerative diseases. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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