Brain functional connectivity in lung cancer population: an exploratory study.
The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patient...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 2; pp. 369 - 383 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128837728&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128837728 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2018 vid: 12 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128837728 128837728 NLM28290076 10.1007/s11682-017-9697-8 NLM28290076 128837728 ppf: 369 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Brain functional connectivity in lung cancer population: an exploratory study. aug: au: Simó, M. Rifà-Ros, X. Vaquero, L. Ripollés, P. Cayuela, N. Jové, J. Navarro, A. Cardenal, F. Bruna, J. Rodríguez-Fornells, Antoni affil: Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L’Hospitalet de Llobregat, 08907, Barcelona, Spain sug: subj: Magnetic Resonance Imaging Lung Neoplasms Physiopathology Brain Physiopathology Lung Neoplasms Drug Therapy Brain Drug Effects Neural Pathways Neural Pathways Physiopathology Antineoplastic Agents Therapeutic Use Female Cognition Disorders Etiology Prospective Studies Brain Relaxation Lung Neoplasms Brain Mapping Methods Neuropsychological Tests Cognition Disorders Physiopathology Platinum Compounds Therapeutic Use Antineoplastic Agents Adverse Effects Middle Age Platinum Compounds Adverse Effects Cognition Disorders Male Clinical Assessment Tools Middle Aged: 45-64 years Female Male ab: The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network. Whereas DMN showed decreased connectivity, the other RSNs exhibited increased connectivity in both LC groups compared to HC and in C+ in comparison to C-. MVPA discriminated significantly and accurately between all groups. Our study showed that disrupted functional connectivity associated with cancer and chemotherapy-induced cognitive deficits is not only related to DMN decreased connectivity abnormalities but also to an increased connectivity of other RSNs, suggesting a potential compensatory mechanism. Graphical abstract. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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