Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia.
Several models have been proposed to account for observed overlaps in clinical features and genetic predisposition between schizophrenia and autism spectrum disorder. This study assessed similarities and differences in topological patterns and vectors of glucose metabolism in both disorders in refer...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 2; pp. 532 - 547 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128837747&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128837747 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2018 vid: 12 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128837747 128837747 NLM28425060 10.1007/s11682-017-9721-z NLM28425060 128837747 ppf: 532 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. aug: au: Mitelman, Serge A. Bralet, Marie-Cecile Mehmet Haznedar, M. Hollander, Eric Shihabuddin, Lina Hazlett, Erin A. Buchsbaum, Monte S. affil: Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, 10029, New York, NY, USA sug: subj: Schizophrenia Metabolism Brain Metabolism Glucose Metabolism Tomography, Emission-Computed Adult Radiopharmaceuticals Female Magnetic Resonance Imaging Brain Brain Mapping Male Social Behavior Fludeoxyglucose F 18 Psychology Schizophrenia Learning Scales Social Readjustment Rating Scale Adult: 19-44 years Female Male ab: Several models have been proposed to account for observed overlaps in clinical features and genetic predisposition between schizophrenia and autism spectrum disorder. This study assessed similarities and differences in topological patterns and vectors of glucose metabolism in both disorders in reference to these models. Co-registered 18fluorodeoxyglucose PET and MRI scans were obtained in 41 schizophrenia, 25 ASD, and 55 healthy control subjects. AFNI was used to map cortical and subcortical regions of interest. Metabolic rates were compared between three diagnostic groups using univariate and multivariate repeated-measures ANOVA. Compared to controls, metabolic rates in schizophrenia subjects were decreased in the frontal lobe, anterior cingulate, superior temporal gyrus, amygdala and medial thalamic nuclei; rates were increased in the occipital cortex, hippocampus, basal ganglia and lateral thalamic nuclei. In ASD subjects metabolic rates were decreased in the parietal lobe, frontal premotor and eye-fields areas, and amygdala; rates were increased in the posterior cingulate, occipital cortex, hippocampus and basal ganglia. In relation to controls, subjects with ASD and schizophrenia showed opposite changes in metabolic rates in the primary motor and somatosensory cortex, anterior cingulate and hypothalamus; similar changes were found in prefrontal and occipital cortices, inferior parietal lobule, amygdala, hippocampus, and basal ganglia. Schizophrenia and ASD appear to be associated with a similar pattern of metabolic abnormalities in the social brain. Divergent maladaptive trade-offs, as postulated by the diametrical hypothesis of their evolutionary relationship, may involve a more circumscribed set of anterior cingulate, motor and somatosensory regions and the specific cognitive functions they subserve. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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