Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis.
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to inv...
| Publicado en: | Brain Imaging & Behavior Vol. 12; no. 2; pp. 547 - 564 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128837748&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128837748 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2018 vid: 12 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128837748 128837748 NLM28425061 128837748 10.1007/s11682-017-9722-y NLM28425061 128837748 ppf: 547 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gray matter and white matter changes in non-demented amyotrophic lateral sclerosis patients with or without cognitive impairment: A combined voxel-based morphometry and tract-based spatial statistics whole-brain analysis. aug: au: Christidi, Foteini Karavasilis, Efstratios Riederer, Franz Zalonis, Ioannis Ferentinos, Panagiotis Velonakis, Georgios Xirou, Sophia Rentzos, Michalis Argiropoulos, Georgios Zouvelou, Vasiliki Zambelis, Thomas Athanasakos, Athanasios Toulas, Panagiotis Vadikolias, Konstantinos Efstathopoulos, Efstathios Kollias, Spyros Karandreas, Nikolaos Kelekis, Nikolaos Evdokimidis, Ioannis affil: First Department of Neurology, Aeginition Hospital, Medical School, National & Kapodistrian University, Athens, Greece sug: subj: Amyotrophic Lateral Sclerosis Psychosocial Factors Amyotrophic Lateral Sclerosis Brain Gray Matter Pathology Magnetic Resonance Imaging Body Weights and Measures Neuroradiography Human Middle Age Diagnostic Imaging Brain Pathology Male Amyotrophic Lateral Sclerosis Pathology Models, Statistical Female Imaging, Three-Dimensional Gray Matter Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Male Female ab: The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner. Voxel-based morphometry and tract-based spatial-statistics analysis were performed to examine GM volume (GMV) changes and WM differences in fractional anisotropy (FA), axial and radial diffusivity (AD, RD, respectively). Compared to HC, ALS-motor patients showed decreased GMV in frontal and cerebellar areas and increased GMV in right supplementary motor area, while ALS-plus patients showed diffuse GMV reduction in primary motor cortex bilaterally, frontotemporal areas, cerebellum and basal ganglia. ALS-motor patients had increased GMV in left precuneus compared to ALS-plus patients. We also found decreased FA and increased RD in the corticospinal tract bilaterally, the corpus callosum and extra-motor tracts in ALS-motor patients, and decreased FA and increased AD and RD in motor and several WM tracts in ALS-plus patients, compared to HC. Multimodal neuroimaging confirms motor and extra-motor GM and WM abnormalities in non-demented cognitively-impaired ALS patients (ALS-plus) and identifies early extra-motor brain pathology in ALS patients without cognitive impairment (ALS-motor). pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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