Efficacy of ultrasound-guided core needle biopsy in cervical lymphadenopathy: A retrospective study of 6,695 cases.
Objectives: To determine the diagnostic yield of ultrasound-guided core needle biopsy (US-CNB) in cervical lymphadenopathy and identify the factors influencing the diagnostic accuracy of US-CNB.Methods: We retrospectively reviewed the records of 6,603 patients with cervical lymphadenopathy who under...
| Published in: | European Radiology Vol. 28; no. 5; pp. 1809 - 1818 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
May2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128864671&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128864671 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2018 vid: 28 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128864671 128864671 NLM29188372 128864671 10.1007/s00330-017-5116-1 NLM29188372 128864671 ppf: 1809 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Efficacy of ultrasound-guided core needle biopsy in cervical lymphadenopathy: A retrospective study of 6,695 cases. aug: au: Han, Feng Xu, Min Xie, Ting Wang, Jian-Wei Lin, Qing-Guang Guo, Zhi-Xing Zheng, Wei Han, Jing Lin, Xi Zou, Ru-Hai Zhou, Jian-Hua Li, An-Hua affil: Department of Ultrasound, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, Guangdong Province, People’s Republic of China sug: subj: Head and Neck Neoplasms Diagnosis Biopsy Methods Biopsy, Needle Methods Lymph Nodes Pathology Ultrasonography Methods Human Child Adult Middle Age Neoplasm Metastasis Diagnosis Adolescence Male Child, Preschool Neck Retrospective Design Diagnosis, Differential Aged, 80 and Over Female Young Adult Head and Neck Neoplasms Aged Validation Studies Comparative Studies Evaluation Research Multicenter Studies Child: 6-12 years Adult: 19-44 years Middle Aged: 45-64 years Adolescent: 13-18 years Child, Preschool: 2-5 years Aged, 80 & over Aged: 65+ years Male Female ab: Objectives: To determine the diagnostic yield of ultrasound-guided core needle biopsy (US-CNB) in cervical lymphadenopathy and identify the factors influencing the diagnostic accuracy of US-CNB.Methods: We retrospectively reviewed the records of 6,603 patients with cervical lymphadenopathy who underwent 6695 US-CNB procedures between 2004 and 2017.Results: Adequate specimens were obtained in 92.19 % (6,172/6,695) of cases. Most lymph nodes (67.65 %) were malignant (metastatic carcinoma 4,131; lymphoma 398). The overall accuracy of US-CNB for differentiating benign from malignant lesions was 91.70 % (6,139/6,695). Among biopsies in which adequate material was obtained, the sensitivity, specificity and accuracy of US-CNB were 99.70 %, 100 % and 99.46 %, respectively. The success or failure of US-CNB for the diagnosis of lymphadenopathy was significantly correlated with node size, nature (malignant vs. benign), and location as well as penetration depth, but not with needle size (p = 0.665), number of core tissues obtained (p = 0.324), or history of malignancy (p = 0.060). There were no major procedure-related complications.Conclusions: US-CNB is a safe and effective method of diagnosing cervical lymphadenopathy, and our findings may help optimise the sampling procedure by maximising its diagnostic accuracy and preserving its minimally invasive nature.Key Points: • US-CNB is useful for the diagnosis of cervical lymphadenopathy. • US-CNB is safe to perform on lymph nodes located near vital structures. • Larger, malignant, level IV lymph nodes yield sufficient tissue samples more easily. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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