Anatomical Road Mapping Using CT and MR Enterography for Ultrasound Molecular Imaging of Small Bowel Inflammation in Swine.
Objectives: To evaluate the feasibility and time saving of fusing CT and MR enterography with ultrasound for ultrasound molecular imaging (USMI) of inflammation in an acute small bowel inflammation of swine.Methods: Nine swine with ileitis were scanned with either CT (n = 3) or MR (n = 6) enterograp...
| Publicado en: | European Radiology Vol. 28; no. 5; pp. 2068 - 2077 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128864682&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128864682 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2018 vid: 28 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128864682 128864682 NLM29170798 10.1007/s00330-017-5148-6 NLM29170798 128864682 ppf: 2068 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Anatomical Road Mapping Using CT and MR Enterography for Ultrasound Molecular Imaging of Small Bowel Inflammation in Swine. aug: au: Wang, Huaijun Felt, Stephen A. Guracar, Ismayil Taviani, Valentina Zhou, Jianhua Sigrist, Rosa Maria Silveira Zhang, Huiping Liau, Joy Vilches-Moure, José G. Tian, Lu Saenz, Yamil Bettinger, Thierry Hargreaves, Brian A. Lutz, Amelie M. Willmann, Jürgen K. affil: Department of Radiology, Stanford University, School of Medicine, 300 Pasteur Drive, Room H1307, 94305-5621, Stanford, CA, USA sug: subj: Magnetic Resonance Imaging Methods Tomography, X-Ray Computed Methods Ileitis Diagnosis Molecular Imaging Methods Ultrasonography Methods Intestine, Small Swine Inflammation Diagnosis Animals Scales ab: Objectives: To evaluate the feasibility and time saving of fusing CT and MR enterography with ultrasound for ultrasound molecular imaging (USMI) of inflammation in an acute small bowel inflammation of swine.Methods: Nine swine with ileitis were scanned with either CT (n = 3) or MR (n = 6) enterography. Imaging times to load CT/MR images onto a clinical ultrasound machine, fuse them to ultrasound with an anatomical landmark-based approach, and identify ileitis were compared to the imaging times without anatomical road mapping. Inflammation was then assessed by USMI using dual selectin-targeted (MBSelectin) and control (MBControl) contrast agents in diseased and healthy control bowel segments, followed by ex vivo histology.Results: Cross-sectional image fusion with ultrasound was feasible with an alignment error of 13.9 ± 9.7 mm. Anatomical road mapping significantly reduced (P < 0.001) scanning times by 40%. Localising ileitis was achieved within 1.0 min. Subsequently performed USMI demonstrated significantly (P < 0.001) higher imaging signal using MBSelectin compared to MBControl and histology confirmed a significantly higher inflammation score (P = 0.006) and P- and E-selectin expression (P ≤ 0.02) in inflamed vs. healthy bowel.Conclusions: Fusion of CT and MR enterography data sets with ultrasound in real time is feasible and allows rapid anatomical localisation of ileitis for subsequent quantification of inflammation using USMI.Key Points: • Real-time fusion of CT/MRI with ultrasound to localise ileitis is feasible. • Anatomical road mapping using CT/MRI significantly decreases the scanning time for USMI. • USMI allows quantification of inflammation in swine, verified with ex vivo histology. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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