Validation of goose liver fat measurement by QCT and CSE-MRI with biochemical extraction and pathology as reference.
Objectives: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis.Methods: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and C...
| Publicado en: | European Radiology Vol. 28; no. 5; pp. 2003 - 2013 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128864708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128864708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2018 vid: 28 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128864708 128864708 NLM29238866 128864708 10.1007/s00330-017-5189-x NLM29238866 128864708 ppf: 2003 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Validation of goose liver fat measurement by QCT and CSE-MRI with biochemical extraction and pathology as reference. aug: au: Xu, Li Duanmu, Yangyang Blake, Glen M. Zhang, Chenxin Zhang, Yong Brown, Keenan Wang, Xiaoqi Wang, Peng Zhou, Xingang Zhang, Manling Wang, Chao Guo, Zhe Guglielmi, Giuseppe Cheng, Xiaoguang affil: Department of Radiology, Beijing Jishuitan Hospital, 31 Xinjiekou East Street, 100035, Beijing, China sug: subj: Fatty Liver Magnetic Resonance Imaging Methods Tomography, X-Ray Computed Methods Animal Studies Human Liver Poultry Models, Biological Male Liver Pathology Fatty Liver Pathology Female Reproducibility of Results Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Male Female ab: Objectives: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis.Methods: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical measurement and histology. Fat percentages by QCT and proton density fat fraction by MRI (MRI-PDFF) were measured within the sample regions of biochemical measurement and histology. The accuracy of QCT and MR measurements were assessed through Spearman correlation coefficients (r) and Passing and Bablok regression equations using biochemical measurement as the "gold standard".Results: Both QCT and MRI correlated highly with chemical extraction [r = 0.922 (p < 0.001) and r = 0.949 (p < 0.001) respectively]. Chemically extracted triglyceride was accurately predicted by both QCT liver fat percentages (Y = 0.6 + 0.866 × X) and by MRI-PDFF (Y = -1.8 + 0.773 × X).Conclusions: QCT and CSE-MRI measurements of goose liver fat were accurate and reliable compared with biochemical measurement.Key Points: • QCT and CSE-MRI can measure liver fat content accurately and reliably • Histological grading of hepatic steatosis has larger sampling variability • QCT and CSE-MRI have potential in the clinical setting. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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