Hemispherical photoacoustic imaging of myocardial infarction: in vivo detection and monitoring.
Objectives: This study aimed to demonstrate the capacity for noninvasive localisation and characterisation of myocardial infarction (MI) in vivo using a hemispherical photoacoustic imaging (PAI) system. MI remains a leading cause of morbidity and mortality worldwide. To enable optimal treatment of p...
| Publicado en: | European Radiology Vol. 28; no. 5; pp. 2176 - 2184 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128864715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128864715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2018 vid: 28 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 128864715 128864715 NLM29270643 128864715 10.1007/s00330-017-5209-x NLM29270643 128864715 ppf: 2176 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hemispherical photoacoustic imaging of myocardial infarction: in vivo detection and monitoring. aug: au: Lv, Jing Peng, Ya Li, Shi Guo, Zhide Zhao, Qingliang Zhang, Xianzhong Nie, Liming affil: State Key Laboratory of Molecular Vaccinology and Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiang’an South Road, Xiang’an District, 361102, Xiamen, Fujian Province, People’s Republic of China sug: subj: Monitoring, Physiologic Methods Diagnostic Imaging Methods Coronary Vessels Myocardial Infarction Diagnosis Male Animal Studies Mice Models, Biological Male ab: Objectives: This study aimed to demonstrate the capacity for noninvasive localisation and characterisation of myocardial infarction (MI) in vivo using a hemispherical photoacoustic imaging (PAI) system. MI remains a leading cause of morbidity and mortality worldwide. To enable optimal treatment of patients, timely and accurate diagnosis and longitudinal monitoring is critical.Methods: Ischaemia was induced in Balb/c mice by ligation of the left anterior descending artery. The hemispherical PAI system, equipped with 128 ultrasonic transducers spirally distributed on the surface, along with parallel data acquisition, was applied for imaging of the mouse heart.Results: Our study showed that hemispherical PAI can delineate thoracic vessels and the morphology of the entire heart. Longitudinal PAI images revealed gradual expansion of the infarcted area along with necrosis and fibrosis, which were quantitatively validated by triphenyltetrazolium chloride staining. After MI modelling, the photoacoustic (PA) signal intensity decreased by 399.1 ± 56.3 (p < 0.001), a ~2.5-fold reduction compared to that of healthy cardiac tissue. The calculated size of the enlarged heart, 10.4 ± 6.0 mm2 (p < 0.001), represents an increase of ~18% versus that of a healthy heart.Conclusions: PAI enables MI diagnosis and injury localisation with its capabilities for both deep organ imaging and lesion region differentiation.Key Points: • Photoacoustic imaging (PAI), combining optical absorption and ultrasonic resolution, can delineate cardiac anatomy. • PAI can diagnose myocardial infarction lesions with 10 mm imaging depth in vivo. • Quantified results are in excellent agreement with enzyme and histological examinations. • PAI can serve as a complementary modality to SPECT and ultrasound imaging. • This study will encourage further PAI development for clinical use. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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