Genetic Algorithm Based Design and Experimental Characterization of a Highly Thermostable Metalloprotein.

The development of thermostable and solvent-tolerant metalloproteins is a long-sought goal for many applications in synthetic biology and biotechnology. In this work, we were able to engineer a highly thermostable and organic solvent-stable metallo variant of the B1 domain of protein G (GB1) with a...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 140; no. 13; pp. 4517 - 4522
Main Authors:	Bozkurt, Esra, Perez, Marta A. S., Hovius, Ruud, Browning, Nicholas J., Rothlisberger, Ursula
Format:	Article
Published:	American Chemical Society 4/4/2018
Subjects:	Structural optimization Genetic algorithms Synthetic biology Metalloproteins Molecular dynamics Mathematical models
Online Access:	View this record in EBSCOhost