Sensory Over‐Responsiveness among Healthy Subjects is Associated with a Pronociceptive State.
Abstract: Objective: Chronic pain patients show hypersensitivity to sensory nonpainful stimuli. Sensory over‐responsiveness (SOR) to innocuous daily stimuli, experienced as painful, is prevalent in 10% of the healthy population. This altered sensory processing may be an expression of overfacilitatio...
| Publicado en: | Pain Practice Vol. 18; no. 4; pp. 473 - 487 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=128973800&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 128973800 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307085 HYN jtl: Pain Practice issn: 15307085 maglogo: Y pubinfo: dt: Apr2018 vid: 18 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 128973800 128973800 128973800 10.1111/papr.12619 128973800 ppf: 473 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Sensory Over‐Responsiveness among Healthy Subjects is Associated with a Pronociceptive State. aug: au: Weissman‐Fogel, Irit Granovsky, Yelena Bar‐Shalita, Tami affil: Physical Therapy Department, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel sug: subj: Sensory Stimulation Pain Psychosocial Factors Research Subjects Psychosocial Factors Human Hyperalgesia Adaptation, Psychological Pain Management Psychophysics Questionnaires Learning Sensation ab: Abstract: Objective: Chronic pain patients show hypersensitivity to sensory nonpainful stimuli. Sensory over‐responsiveness (SOR) to innocuous daily stimuli, experienced as painful, is prevalent in 10% of the healthy population. This altered sensory processing may be an expression of overfacilitation, or a less efficient pain‐inhibitory process in the pain pathways. We therefore aimed to investigate specifically the pain‐inhibitory system of subjects with SOR who are otherwise healthy, not studied as of yet. Methods: Thirty healthy subjects, divided into an SOR group (<italic>n </italic>=<italic> </italic>14) and a non‐SOR group (<italic>n </italic>=<italic> </italic>16) based on responses to the Sensory Responsiveness Questionnaire, were psychophysically tested in order to evaluate (1) hyperalgesic responses; (2) adaptation/sensitization to 14 phasic heat stimuli; (3) habituation; (4) 6‐minute after‐sensations; and (5) conditioned pain modulation (CPM) (ie, phasic heat stimuli applied with and without hand immersion in a hot water bath). Results: The SOR group differed from the non‐SOR group in (1) a steeper escalation in NPS ratings to temperature increase (<italic>P </italic>=<italic> </italic>0.003), indicating hyperalgesia; (2) increased sensitization (<italic>P </italic><<italic> </italic>0.001); (3) habituation responses (<italic>P </italic><<italic> </italic>0.001); (4) enhanced pain ratings during the after‐sensation (<italic>P = </italic>0.006); and (5) no group difference was found in CPM. Conclusions: SOR is associated with a pronociceptive state, expressed by amplification of experimental pain, yet with sufficient inhibitory processes. Our results support previous findings of enhanced facilitation of pain‐transmitting pathways but also reveal preserved inhibitory mechanisms, although they were slower to react. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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