Can Preoperative Peak Expiratory Flow Predict Postoperative Pulmonary Complications in Lung Cancer Patients Undergoing Lobectomy?

Background and objective Postoperative pulmonary complications (PPCs), especially postoperative pneumonia (POP), directly affect the rapid recovery of lung cancer patients after surgery. Peak expiratory flow (PEF) can reflect airway patency and cough efficiency. Moreover, cough impairment may lead t...

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Publicado en:Chinese Journal of Lung Cancer Vol. 20; no. 9; pp. 603 - 610
Autores principales: Kun ZHOU, Yanming WU, Jianhua SU, Yutian LAI, Cheng SHEN, Pengfei LI, Guowei CHE
Formato: research tables/charts Journal Article
Publicado: Chinese Journal of Lung Cancer 2017
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Chinese Journal of Lung Cancer
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        10.3779/j.issn.1009-3419.2017.09.03
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        atl: Can Preoperative Peak Expiratory Flow Predict Postoperative Pulmonary Complications in Lung Cancer Patients Undergoing Lobectomy?
      aug:
        au:
          Kun ZHOU
          Yanming WU
          Jianhua SU
          Yutian LAI
          Cheng SHEN
          Pengfei LI
          Guowei CHE
        affil: Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
      sug:
        subj:
          Peak Expiratory Flow Rate
          Postoperative Complications Risk Factors
          Lung Neoplasms Surgery
          Pneumonectomy
          Human
          China
          Pneumonia
          Retrospective Design
          Regression
          Academic Medical Centers
      ab: Background and objective Postoperative pulmonary complications (PPCs), especially postoperative pneumonia (POP), directly affect the rapid recovery of lung cancer patients after surgery. Peak expiratory flow (PEF) can reflect airway patency and cough efficiency. Moreover, cough impairment may lead to accumulation of pulmonary secretions which can increase the risk of PPCs. The aim of this study is to investigate the effect of preoperative PEF on PPCs in patients with lung cancer. Methods Retrospective research was conducted on 433 lung cancer patients who underwent lobectomy at the West China Hospital of Sichuan University from January 2014 to December 2015. The associations between preoperative PEF and PPCs were analyzed based on patients' basic characteristics and clinical data in hospital. Results Preoperative PEF value in PPCs group (280.93±88.99) L/min was significantly lower than that in non-PPCs group (358.38±93.69) L/min (P<0.001). According to the binary logistics regression analysis, PEF and operative time were independent risk factors for PPCs. Further, ROC curve showed that PEF=320 L/min was the cut-off value for predicting the occurrence of PPCs (AUC=0.706, 95%CI: 0.661-0.749). The incidence of PPCs in PEF<320 L/min group (26.6%) was significantly higher than that in PEF>320 L/min group (9.4%)(P<0.001). Conclusion Preoperative PEF and PPCs are correlated, and PEF may be used as a predictor of PPCs.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: Chinese
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