Fat poor angiomyolipoma differentiation from renal cell carcinoma at 320-slice dynamic volume CT perfusion.
Purpose: To compare various CT perfusion features of fat poor angiomyolipoma (AML) with those of size-matched renal cell carcinoma (RCC).Methods: One hundred and seventy-four patients [16 with fat poor AML (mean diameter, 3.1 cm; range, 1.5-5.5 cm) and 158 with RCC (mean diameter, 3.2 cm; range, 2.4...
| Publicado en: | Abdominal Radiology Vol. 43; no. 5; pp. 1223 - 1231 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129132782&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129132782 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: May2018 vid: 43 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129132782 10.1007/s00261-017-1286-1 129132782 ppf: 1223 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Fat poor angiomyolipoma differentiation from renal cell carcinoma at 320-slice dynamic volume CT perfusion. aug: au: Chen, Chao Kang, Qinqin Xu, Bing Shi, Zhang Guo, Hairuo Wei, Qiang Lu, Yayun Wu, Xinhuai affil: Department of Radiology, PLA Army General Hospital, No. 5 Nanmencang Hutong, Dongcheng District, 100700, Beijing, China sug: ab: Purpose: To compare various CT perfusion features of fat poor angiomyolipoma (AML) with those of size-matched renal cell carcinoma (RCC).Methods: One hundred and seventy-four patients [16 with fat poor AML (mean diameter, 3.1 cm; range, 1.5-5.5 cm) and 158 with RCC (mean diameter, 3.2 cm; range, 2.4-5.4 cm)] who had undergone 320-slice dynamic volume CT perfusion were evaluated. Equivalent blood volume (<italic>BV</italic>Equiv), permeability surface-area product (PS), and blood flow (BF) of tumor were measured and analyzed. Fat poor AML was compared with each subtype of RCC (132 clear cell, 9 papillary, and 17 chromophobe). Receiver operating characteristic (ROC) curve analysis was performed for the comparison of fat poor AML and RCC. ROC curve analysis was not performed for the papillary RCC subtype because of the small number of masses of this subtype.Results: <italic>BV</italic>Equiv and BF were significantly lower in fat poor AML than in clear cell RCC (<italic>P</italic> < 0.05 for both). Fat poor AML had higher <italic>BV</italic>Equiv, PS, and BF than papillary RCC (<italic>P</italic> < 0.05 for all). PS and BF in fat poor AML significantly exceeded those in chromophobe RCC (<italic>P</italic> < 0.05 for both). For differentiating fat poor AML from clear cell RCC, area under the ROC curve (AUC) of <italic>BV</italic>Equiv and BF were 0.82 and 0.69. Using the optimal threshold value, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 0.82, 0.81, 0.35, 0.97 for <italic>BV</italic>Equiv and 0.71, 0.75, 0.24, 0.96 for BF, respectively. For differentiating fat poor AML from chromophobe RCC, AUC of PS and BF were 0.77 and 0.79, respectively. The optimal sensitivity, specificity, PPV, and NPV were 0.77, 0.75, 0.75, 0.76 for PS and 0.71, 0.81, 0.72, 0.80 for BF, respectively.Conclusions: Fat poor AML and subtypes of RCCs demonstrate different perfusion features at 320-slice dynamic volume CT, allowing their differentiations with <italic>BV</italic>Equiv, PS, and BF being valuable perfusion parameters. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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