Comparison of quantitative apparent diffusion coefficient parameters with prostate imaging reporting and data system V2 assessment for detection of clinically significant peripheral zone prostate cancer.
Purpose: To compare diagnostic performance of PI-RADSv2 with ADC parameters to identify clinically significant prostate cancer (csPC) and to determine the impact of csPC definitions on diagnostic performance of ADC and PI-RADSv2.Methods: We retrospectively identified treatment-naïve pathology-proven...
| Published in: | Abdominal Radiology Vol. 43; no. 5; pp. 1237 - 1245 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
May2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129132791&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129132791 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: May2018 vid: 43 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129132791 10.1007/s00261-017-1297-y 129132791 ppf: 1237 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of quantitative apparent diffusion coefficient parameters with prostate imaging reporting and data system V2 assessment for detection of clinically significant peripheral zone prostate cancer. aug: au: Hassanzadeh, Elmira Alessandrino, Francesco Olubiyi, Olutayo I. Glazer, Daniel I. Mulkern, Robert V. Fedorov, Andriy Tempany, Clare M. Fennessy, Fiona M. affil: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, 02115, Boston, MA, USA sug: ab: Purpose: To compare diagnostic performance of PI-RADSv2 with ADC parameters to identify clinically significant prostate cancer (csPC) and to determine the impact of csPC definitions on diagnostic performance of ADC and PI-RADSv2.Methods: We retrospectively identified treatment-naïve pathology-proven peripheral zone PC patients who underwent 3T prostate MRI, using high<italic> b</italic>-value diffusion-weighted imaging from 2011 to 2015. Using 3D slicer, areas of suspected tumor (T) and normal tissue (N) on ADC (<italic>b</italic> = 0, 1400) were outlined volumetrically. Mean ADCT, mean ADCN, ADCratio (ADCT/ADCN) were calculated. PI-RADSv2 was assigned. Three csPC definitions were used: (A) Gleason score (GS) ≥ 4 + 3; (B) GS ≥ 3 + 4; (C) MRI-based tumor volume >0.5 cc. Performances of ADC parameters and PI-RADSv2 in identifying csPC were measured using nonparametric comparison of receiver operating characteristic curves using the area under the curve (AUC).Results: Eighty five cases met eligibility requirements. Diagnostic performances (AUC) in identifying csPC using three definitions were: (A) ADCT (0.83) was higher than PI-RADSv2 (0.65, <italic>p</italic> = 0.006); (B) ADCT (0.86) was higher than ADCratio (0.68, <italic>p</italic> < 0.001), and PI-RADSv2 (0.70, <italic>p</italic> = 0.04); (C) PI-RADSv2 (0.73) performed better than ADCratio (0.56, <italic>p</italic> = 0.02). ADCT performance was higher when csPC was defined by A or B versus C (<italic>p</italic> = 0.038 and <italic>p</italic> = 0.01, respectively). ADCratio performed better when csPC was defined by A versus C (<italic>p</italic> = 0.01). PI-RADSv2 performance was not affected by csPC definition.Conclusions: When csPC was defined by GS, ADC parameters provided better csPC discrimination than PI-RADSv2, with ADCT providing best result. When csPC was defined by MRI-calculated volume, PI-RADSv2 provided better discrimination than ADCratio. csPC definition did not affect PI-RADSv2 diagnostic performance. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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