Computational analysis of the effect of mitral and aortic regurgitation on the function of ventricular assist devices using 3D cardiac electromechanical model.
Valvular insufficiency affects cardiac responses and the pumping efficacy of left ventricular assist devices (LVADs) when patients undergo LVAD therapy. Knowledge of the effect of valvular regurgitation on the function of LVADs is important when treating heart failure patients. The goal of this stud...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 56; no. 5; pp. 889 - 899 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129156214&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129156214 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: May2018 vid: 56 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129156214 129156214 NLM29080191 129156214 10.1007/s11517-017-1727-6 NLM29080191 129156214 ppf: 889 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Computational analysis of the effect of mitral and aortic regurgitation on the function of ventricular assist devices using 3D cardiac electromechanical model. aug: au: Kim, Yoo Seok Yuniarti, Ana R. Song, Kwang-Soup Trayanova, Natalia A. Shim, Eun Bo Lim, Ki Moo affil: Department of IT Convergence Engineering, Kumoh National Institute of Technology, 61 Daehak-ro, 39253, Gumi, Gyeongbuk, Republic of South Korea sug: subj: Aortic Valve Insufficiency Therapy Imaging, Three-Dimensional Mitral Valve Insufficiency Therapy Heart Assist Devices Models, Biological Heart Ventricle Pathology Finite Element Analysis Pressure Myocardium Pathology Funding Source Human ab: Valvular insufficiency affects cardiac responses and the pumping efficacy of left ventricular assist devices (LVADs) when patients undergo LVAD therapy. Knowledge of the effect of valvular regurgitation on the function of LVADs is important when treating heart failure patients. The goal of this study was to examine the effect of valvular regurgitation on the ventricular mechanics of a heart under LVAD treatment and the pumping efficacy of an LVAD using a computational model of the cardiovascular system. For this purpose, a 3D electromechanical model of failing ventricles in a human heart was coupled with a lumped-parameter model of valvular regurgitation and an LVAD-implanted vascular system. We used the computational model to predict cardiac responses with respect to the severity of valvular regurgitation in the presence of LVAD treatment. An LVAD could reduce left ventricle (LV) pressure (up to 34%) and end-diastolic ventricular volume (up to 80%) and maintain cardiac output at the estimated flow rate from the LVAD under the condition of mitral regurgitation (MR); however, the opposite would occur under the condition of aortic regurgitation (AR). Considering these physiological responses, we conclude that AR, and not MR, diminishes the pumping function of LVADs. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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