Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study.
Purpose: Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and pre...
| Publicado en: | Supportive Care in Cancer Vol. 26; no. 6; pp. 1917 - 1927 |
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| Autores principales: | , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129323165&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129323165 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Jun2018 vid: 26 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129323165 129323165 NLM29282534 129323165 10.1007/s00520-017-4026-8 NLM29282534 129323165 ppf: 1917 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study. aug: au: Wu, Lisa M. Bovbjerg, Katrin Amidi, Ali Tanenbaum, Molly L. Winkel, Gary Gordon, Wayne A. Hall, Simon J. Diefenbach, Michael A. affil: Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 North St. Clair, 19th floor, 60611, Chicago, IL, USA sug: subj: Prostatic Neoplasms Drug Therapy Androgen Antagonists Therapeutic Use Computer-Assisted Instruction Psychological Techniques Memory Drug Effects Prostatic Neoplasms Psychosocial Factors Middle Age Male Cognition Disorders Therapy Cognition Disorders Chemically Induced Aged Cognition Drug Effects Antineoplastic Agents, Hormonal Therapeutic Use Pilot Studies Human Quality of Life Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Ferrans and Powers Quality of Life Index Middle Aged: 45-64 years Aged: 65+ years Male ab: Purpose: Prostate cancer patients who have undergone androgen deprivation therapy (ADT) may experience cognitive impairment, yet there is an unmet need for nonpharmacological interventions to address cognitive impairment in this population. This study examines the feasibility, acceptability, and preliminary efficacy of a home-based computerized cognitive training (CCT) program to treat cancer-related cognitive impairment.Methods: Sixty men who had received ≥ 3 months of ADT were screened for at least mild cognitive or neurobehavioral impairment and randomized to 8 weeks of CCT or usual care. Follow-up assessments occurred immediately post-intervention or equivalent (T2) and 8 weeks later (T3). The acceptability of CCT was also assessed.Results: Feasibility:A priori feasibility thresholds were partially met (i.e., randomization rate > 50%, retention rate > 70% excluding CCT drop-outs, but < 70% for intent-to-treat). Acceptability: Participants were mostly satisfied with CCT and found it somewhat enjoyable, though barriers to uptake existed. Preliminary efficacy: Linear mixed models indicated significant time by group effects favorable to CCT in reaction time (p = .01), but unfavorable to CCT in verbal and visual memory (ps < .05). Memory was temporarily suppressed in the CCT group at T2, but normalized by T3. There was no effect of CCT on self-reported cognitive functioning, neurobehavioral functioning, nor quality of life.Conclusions: This study provides tentative support for the feasibility and acceptability of CCT to treat mild cognitive impairment in ADT patients. CCT had a beneficial effect on reaction time, but temporarily suppressed memory. CCT's benefits may be limited to a narrow area of functioning. Larger-scale studies are needed. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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