Feedback-Induced Temporal Control of "Breathing" Polymersomes To Create Self-Adaptive Nanoreactors.
Here we present the development of self-regulated "breathing" polymersome nanoreactors that show temporally programmable biocatalysis induced by a chemical fuel. pH-sensitive polymersomes loaded with horseradish peroxidase (HRP) and urease were developed. Addition of an acidic urea solution ("fuel")...
| Publicado en: | Journal of the American Chemical Society Vol. 140; no. 16; pp. 5356 - 5360 |
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| Autores principales: | , , |
| Formato: | Artículo |
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American Chemical Society
4/25/2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=129345656&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 129345656 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 4/25/2018 vid: 140 iid: 16 pid: 997 pub: American Chemical Society artinfo: ui: 129345656 10.1021/jacs.8b02387 ppf: 5356 ppct: 4 formats: tig: atl: Feedback-Induced Temporal Control of "Breathing" Polymersomes To Create Self-Adaptive Nanoreactors. aug: au: Hailong Che Shoupeng Cao van Hest, Jan C. M. affil: Bio-organic Chemistry, Eindhoven University of Technology, P.O. Box 513 (STO 3.41), 5600MB Eindhoven, The Netherlands su: Polymersomes Biocatalysis Horseradish peroxidase Urease Catalysis Nanomotors Organelles sug: subj: Polymersomes Biocatalysis Horseradish peroxidase Urease Catalysis Nanomotors Organelles ab: Here we present the development of self-regulated "breathing" polymersome nanoreactors that show temporally programmable biocatalysis induced by a chemical fuel. pH-sensitive polymersomes loaded with horseradish peroxidase (HRP) and urease were developed. Addition of an acidic urea solution ("fuel") endowed the polymersomes with a transient size increase and permeability enhancement, driving a temporal "ON" state of the HRP enzymatic catalysis; subsequent depletion of fuel led to shrinking of the polymersomes, resulting in the catalytic "OFF" state. Moreover, the nonequilibrium nanoreactors could be reinitiated several cycles as long as fuel was supplied. This feedback-induced temporal control of catalytic activity in polymersome nanoreactors provides a platform for functional nonequilibrium systems as well as for artificial organelles with precisely controlled adaptivity. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2018 holdings: @attributes: islocal: N |
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