High immune cell score predicts improved survival in pancreatic cancer.
Increasing evidence suggests that cancer progression is strongly influenced by host immune response, which is represented by immune cell infiltrates. T-lymphocyte-based immunoscore has proved to be a prognostic factor in colon cancer, but its significance in pancreatic cancer is poorly known. Total...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 472; no. 4; pp. 653 - 666 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129371104&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129371104 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Apr2018 vid: 472 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129371104 129371104 NLM29356891 129371104 10.1007/s00428-018-2297-1 NLM29356891 129371104 ppf: 653 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: High immune cell score predicts improved survival in pancreatic cancer. aug: au: Tahkola, Kyösti Mecklin, Jukka-Pekka Wirta, Erkki-Ville Ahtiainen, Maarit Helminen, Olli Böhm, Jan Kellokumpu, Ilmo affil: Department of Surgery, Central Finland Central Hospital, Keskussairaalantie 19, 40620, Jyväskylä, Finland sug: subj: Pancreatic Neoplasms Immunology Carcinoma, Ductal Immunology Lymphocytes Immunology Cell Physiology Immunology Female Aged, 80 and Over Pancreatic Neoplasms Mortality Carcinoma, Ductal Mortality Adult Kaplan-Meier Estimator Aged Prognosis Middle Age Cox Proportional Hazards Model Male Human Aged, 80 & over Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Increasing evidence suggests that cancer progression is strongly influenced by host immune response, which is represented by immune cell infiltrates. T-lymphocyte-based immunoscore has proved to be a prognostic factor in colon cancer, but its significance in pancreatic cancer is poorly known. Total of 108 patients operated (R0/R1) for pancreatic ductal adenocarcinoma (PDAC) (TNM stage I-II) were included in the study. Immune cell score (IS) was determined by scoring the samples from grade 0 to 4 according to the number of immune cells (CD3+ and CD8+) in tumor core and invasion margin using tissue microarrays, immunohistochemistry, and digital analysis. Tumors with microsatellite instability were identified by MLH1 immunostaining. High IS and low histological grade were significantly associated with better disease-specific survival (DSS) and overall survival (OS). The 5-year DSS rate for low, moderate, and high IS groups were 5.0, 15.2, and 33.4%, respectively (p = 0.007). The 5-year OS rate for the low, moderate, and high IS groups were 4.2, 13.4, and 31.5%, respectively (p = 0.004). In addition, IS and prognosis varied within a single TNM stage. There was no association between IS and any of the clinicopathological variables. IS was shown to be an independent prognostic factor for better DSS and OS in multivariate analysis, together with the histological grade of the tumor and perineural invasion. Five MLH1-negative tumors (4.6%) were found showing no correlation with IS. IS could be a useful prognostic marker in patients with PDAC treated by primary surgery. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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