High-Frequency Airway Oscillating Device for Respiratory Muscle Training in Subjects With COPD.
BACKGROUND: COPD is characterized by expiratory flow limitation, which results in symptomatic dyspnea and reduced exercise capacity. Changes in breathing mechanics mean the respiratory muscles are unable to respond to the ventilatory demands, increasing the sensation of dyspnea. A high-frequency osc...
| Publicado en: | Respiratory Care Vol. 63; no. 5; pp. 584 - 591 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129399399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129399399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: May2018 vid: 63 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 129399399 129399399 129399399 10.4187/respcare.05837 129399399 ppf: 584 ppct: 7 formats: fmt: @attributes: type: P tig: atl: High-Frequency Airway Oscillating Device for Respiratory Muscle Training in Subjects With COPD. aug: au: Daynes, Enya Greening, Neil J. Harvey-Dunstan, Theresa C. Singh, Sally J. affil: Centre for Exercise & Rehabilitation Science, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, and the University of Leicester, Leicester, United Kingdom sug: subj: Ventilation, High Frequency Technology, Medical Oscillator Pulmonary Disease, Chronic Obstructive Therapy Human Equipment and Supplies Muscle Strengthening Methods Pulmonary Disease, Chronic Obstructive Complications Respiration Respiratory Muscles Dyspnea Diagnosis Respiratory Function Tests Forced Expiratory Volume Vital Capacity Rehabilitation Descriptive Statistics Lung Diseases Diagnosis Positive Pressure Ventilation Wilcoxon Rank Sum Test ab: BACKGROUND: COPD is characterized by expiratory flow limitation, which results in symptomatic dyspnea and reduced exercise capacity. Changes in breathing mechanics mean the respiratory muscles are unable to respond to the ventilatory demands, increasing the sensation of dyspnea. A high-frequency oscillating device has been developed to improve dyspnea in patients with COPD. We conducted a feasibility trial to gain insight into the potential for recruitment, retention, and study design for a future randomized controlled trial. METHODS: Symptomatic subjects with COPD were included on the basis of a Medical Research Council (MRC) score ≥ 3 and FEV1/FVC < 0.70). Patients were excluded if they received pulmonary rehabilitation within the last 6 months. The intervention employed the device for 8 weeks, 3 times daily. Clinical outcomes included the MRC score, maximal expiratory and inspiratory pressures (PEmax/PImax), the incremental shuttle walk test (ISWT), and the endurance shuttle walk test (ESWT). RESULTS: We successfully recruited 23 subjects with established COPD (65.2% male, mean age 65 ± 5.03 y, mean % predicted FEV1 43.9 ± 16, mean FEV1/FVC ratio 0.46 ± 0.13, and median [interquartile range] MRC 4 [3-5]). There was a significant change in MRC from 4 to 3 pre to post intervention (P = .003). There was a statistically significant difference in PEmax P < .008 and PImax P = .044. There were no significant differences observed in the ISWT or ESWT. CONCLUSIONS: This study design appeared feasible to proceed to a clinical effectiveness trial. The use of the device for 8 weeks showed a significant improvement in PEmax, PImax, and reduced symptomatic dyspnea on the MRC dyspnea score. The results of this study should encourage a randomized controlled trial. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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