The instability of functional connectivity in patients with schizophrenia and their siblings: A dynamic connectivity study.
Background: The distributed connectivity among brain regions is in a constant state of flux, even when a subject is at rest. This instability (temporal variability), when optimal, may contribute to efficient cross-network communications. We investigate the role of this variability in the genetic dia...
| Publicado en: | Schizophrenia Research Vol. 195; pp. 183 - 190 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
May2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129448665&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129448665 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: May2018 vid: 195 pid: 1004 pub: Elsevier B.V. artinfo: ui: 129448665 129448665 NLM29153446 129448665 10.1016/j.schres.2017.09.035 NLM29153446 129448665 ppf: 183 ppct: 7 formats: tig: atl: The instability of functional connectivity in patients with schizophrenia and their siblings: A dynamic connectivity study. aug: au: Guo, Shuixia Zhao, Wei Tao, Haojuan Liu, Zhening Palaniyappan, Lena affil: College of Mathematics and Computer Science, Key Laboratory of High Performance Computing and Stochastic Information Processing (Ministry of Education of China), Hunan Normal University, Changsha, PR China sug: subj: Magnetic Resonance Imaging Neural Pathways Siblings Schizophrenia Adult Neural Pathways Pathology Relaxation Image Processing, Computer Assisted Chaos Theory Statistics Young Adult Male Human Female Oxygen Blood Case Control Studies Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adult: 19-44 years Male Female ab: Background: The distributed connectivity among brain regions is in a constant state of flux, even when a subject is at rest. This instability (temporal variability), when optimal, may contribute to efficient cross-network communications. We investigate the role of this variability in the genetic diathesis and symptom expression of schizophrenia.Methods: Resting state functional MRI data acquired from 116 subjects (28 patients with schizophrenia, 28 siblings and 60 matched healthy controls). Using a sliding-window dynamic connectivity approach, we quantified the variability of whole-brain connectivity (dynamic functional connectivity or dFC) of each of the 90 brain regions obtained using a parcellation scheme that covered all contiguous brain regions of the cerebral cortex.Results: We noted a high degree of instability anchored on the precuneus in patients with schizophrenia compared to both healthy controls (t=3.60, p=0.0005) and unaffected siblings (t=3.61, p=0.001) indicating a role for dFC of precuneus in the clinical expression of schizophrenia. Compared to patients, siblings also showed an increase in medial orbitofrontal but reduced putaminal instability; these latter changes were not seen in patients when compared to controls, indicating a lack of specificity for diathesis or expression related effects.Conclusions: Instability in the intrinsic connectivity of precuneus, a functional core hub with a major role in task-free self-processing, is likely to be a core substrate of the clinical expression of schizophrenia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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