Effect of intra-articular injection of intermediate-weight hyaluronic acid on hip and knee cartilage: in-vivo evaluation using T2 mapping.
Objectives: We used T2 mapping to quantify the effect of intra-articular hyaluronic acid administration (IAHAA) on cartilage with correlation to clinical symptoms.Methods: One hundred two patients with clinical and MRI diagnosis of hip or knee grade I-III chondropathy were prospectively included. Al...
| Publicado en: | European Radiology Vol. 28; no. 6; pp. 2345 - 2356 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129492192&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129492192 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2018 vid: 28 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129492192 129492192 NLM29318429 10.1007/s00330-017-5186-0 NLM29318429 129492192 ppf: 2345 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effect of intra-articular injection of intermediate-weight hyaluronic acid on hip and knee cartilage: in-vivo evaluation using T2 mapping. aug: au: Ferrero, Giulio Sconfienza, Luca Maria Fiz, Francesco Fabbro, Emanuele Corazza, Angelo Dettore, Daniele Orlandi, Davide Castellazzo, Carlo Tornago, Stefano Serafini, Giovanni affil: Unit of Diagnostic and Interventional Radiology, Ospedale Santa Corona, Pietra Ligure, Italy sug: subj: Osteoarthritis, Knee Magnetic Resonance Imaging Methods Cartilage, Articular Osteoarthritis, Hip Drug Therapy Hyaluronic Acid Administration and Dosage Cartilage, Articular Drug Effects Solutions Administration and Dosage Young Adult Injections, Intraarticular Middle Age Adolescence Adult Osteoarthritis, Hip Diagnosis Female Osteoarthritis, Knee Diagnosis Male Aged Scales Middle Aged: 45-64 years Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Female Male ab: Objectives: We used T2 mapping to quantify the effect of intra-articular hyaluronic acid administration (IAHAA) on cartilage with correlation to clinical symptoms.Methods: One hundred two patients with clinical and MRI diagnosis of hip or knee grade I-III chondropathy were prospectively included. All patients received a standard MRI examination of the affected hip/knee (one joint/patient) and T2-mapping multiecho sequence for cartilage evaluation. T2 values of all slices were averaged and used for analysis. One month after MR evaluation 72 patients (38 males; mean age 51±10 years) underwent IAHAA. As a control group, 30 subjects (15 males; 51 ± 9 years) were not treated. MR and WOMAC evaluation was performed at baseline and after 3, 9, and 15 months in all patients.Results: T2 mapping in hyaluronic acid (HA) patients showed a significant increase in T2 relaxation times from baseline to the first time point after therapy in knees (40.7 ± 9.8 ms vs. 45.8 ± 8.6 ms) and hips (40.9 ± 9.7 ms; 45.9 ± 9.5 ms) (p < 0.001). At the 9- and 15-month evaluations, T2 relaxation dropped to values similar to the baseline ones (p < 0.001 vs. 3 month). The correlation between T2 increase and pain reduction after IAHAA was statistically significant (r = 0.54, p < 0.01) in patients with grade III chondropathy.Conclusions: T2 mapping can be used to evaluate the effect over time of IAHAA in patients with hip and knee chondropathy.Key Points: • T2 relaxation times change over time after hyaluronic acid intra-articular administration • T2 relaxation times of the medial femoral condyle correlate with WOMAC variation • T2 relaxation times are different between Outerbridge I and II-III. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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