Hepatic neuroendocrine tumour: Apparent diffusion coefficient as a potential marker of prognosis associated with tumour grade and overall survival.
Objectives: To evaluate the correlation between grade of hepatic neuroendocrine tumours (NETs) according to the 2010 World Health Organization (WHO) classification and the apparent diffusion coefficient (ADC) and to assess whether ADC value can predict overall survival (OS) after diagnosis of hepati...
| Publicado en: | European Radiology Vol. 28; no. 6; pp. 2561 - 2572 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129492229&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129492229 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2018 vid: 28 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129492229 129492229 NLM29368162 129492229 10.1007/s00330-017-5248-3 NLM29368162 129492229 ppf: 2561 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hepatic neuroendocrine tumour: Apparent diffusion coefficient as a potential marker of prognosis associated with tumour grade and overall survival. aug: au: Min, Ji Hye Kang, Tae Wook Kim, Young Kon Kim, Seong Hyun Shin, Kyung Sook Lee, Jeong Eun Ha, Sang Yun Sohn, Insuk affil: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Gangnam-gu, 135-710, Seoul, Korea sug: subj: Liver Neoplasms Pathology Neuroendocrine Tumors Pathology Cox Proportional Hazards Model Middle Age Male Retrospective Design Multivariate Analysis Magnetic Resonance Imaging Methods Aged, 80 and Over Human Neuroendocrine Tumors Mortality Aged Prognosis Adult Neoplasm Grading World Health Organization Liver Neoplasms Mortality Female Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Adult: 19-44 years Male Female ab: Objectives: To evaluate the correlation between grade of hepatic neuroendocrine tumours (NETs) according to the 2010 World Health Organization (WHO) classification and the apparent diffusion coefficient (ADC) and to assess whether ADC value can predict overall survival (OS) after diagnosis of hepatic NETs.Methods: The study included 63 patients who underwent magnetic resonance (MR) imaging with diffusion-weighted images for the evaluation of hepatic NETs. The correlation between qualitative and quantitative MR imaging findings, including ADC values, and WHO classifications was assessed. The association between ADC value and OS was analyzed.Results: The ADC values and WHO classification of hepatic NETs were moderately negatively correlated in a statistically significant manner (ρ = -0.57, p < 0.001). The OS rates were significantly different according to the ADC value (low ADC vs. high ADC, p = 0.006) as well as WHO classifications (G1+ G2 vs. G3, p = 0.038). However, multivariate analysis revealed that the only independent predictor for OS was a low ADC value (hazard ratio: 3.37, p = 0.010).Conclusion: There was a significant correlation between the ADC value of hepatic NETs and the WHO tumour grade. Additionally, the ADC value of a hepatic NET might be more accurate than the current WHO tumour grade for predicting OS.Key Points: • ADC values of hepatic NET and WHO tumour grade were negatively correlated. • Lower ADC values of hepatic NET were significantly correlated with worse OS. • ADC value might be more accurate than WHO grade for predicting OS. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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