Myocardial perfusion in patients with suspected coronary artery disease: comparison between 320-MDCT and rubidium-82 PET.
Objectives: Despite advances in non-invasive myocardial perfusion imaging (MPI) evaluation, computed tomography (CT) multiphase MPI protocols have not yet been compared with the highly accurate rubidium-82 positron emission tomography (82RbPET) MPI. Thus, this study aimed to evaluate agreement betwe...
| Publicado en: | European Radiology Vol. 28; no. 6; pp. 2665 - 2675 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129492232&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129492232 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2018 vid: 28 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129492232 129492232 NLM29352381 129492232 10.1007/s00330-017-5257-2 NLM29352381 129492232 ppf: 2665 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Myocardial perfusion in patients with suspected coronary artery disease: comparison between 320-MDCT and rubidium-82 PET. aug: au: Dantas, Roberto Nery Assuncao, Antonildes Nascimento Marques, Ismar Aguiar Fahel, Mateus Guimaraes Nomura, Cesar Higa Avila, Luiz Francisco Rodrigues Giorgi, Maria Clementina Pinto Soares, Jose Meneghetti, Jose Claudio Parga, Jose Rodrigues Dantas, Roberto Nery Jr Assuncao, Antonildes Nascimento Jr Soares, Jose Jr affil: Computed Tomography Department, Heart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil sug: subj: Coronary Arteriosclerosis Radiopharmaceuticals Radioisotopes Male Coronary Vessels Software Middle Age Human Multidetector Computed Tomography Tomography, Emission-Computed Methods Dipyridamole Pharmacodynamics Prospective Studies Female Heart Function Tests Methods Tomography, Emission-Computed, Single-Photon Methods Vasodilator Agents Pharmacodynamics Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Male Female ab: Objectives: Despite advances in non-invasive myocardial perfusion imaging (MPI) evaluation, computed tomography (CT) multiphase MPI protocols have not yet been compared with the highly accurate rubidium-82 positron emission tomography (82RbPET) MPI. Thus, this study aimed to evaluate agreement between 82RbPET and 320-detector row CT (320-CT) MPI using a multiphase protocol in suspected CAD patients.Methods: Forty-four patients referred for MPI evaluation were prospectively enrolled and underwent dipyridamole stress 82RbPET and multiphase 320-CT MPI (five consecutive volumetric acquisitions during stress). Statistical analyses were performed using the R software.Results: There was high agreement for recognizing summed stress scores ≥ 4 (kappa 0.77, 95% CI 0.55-0.98, p < 0.001) and moderate for detecting SDS ≥ 2 (kappa 0.51, 95% CI 0.23-0.80, p < 0.001). In a per segment analysis, agreement was high for the presence of perfusion defects during stress and rest (kappa 0.75 and 0.82, respectively) and was moderate for impairment severity (kappa 0.58 and 0.65, respectively). The 320-CT protocol was safe, with low radiation burden (9.3 ± 2.4 mSv).Conclusions: There was a significant agreement between dipyridamole stress 320-CT MPI and 82RbPET MPI in the evaluation of suspected CAD patients of intermediate risk. The multiphase 320-CT MPI protocol was feasible, diagnostic and with relatively low radiation exposure.Key Points: • Rubidium-82 PET and 320-MDCT can perform MPI studies for CAD investigation. • There is high agreement between rubidium-82 PET and 320-MDCT for MPI assessment. • Multiphase CT perfusion protocols are feasible and with low radiation. • Multiphase CT perfusion protocols can identify image artefacts. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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