Association of Autism with Maternal Infections, Perinatal and Other Risk Factors: A Case-Control Study.

This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178...

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Detalles Bibliográficos
Publicado en:	Journal of Autism & Developmental Disorders Vol. 48; no. 6; pp. 2010 - 2022
Autores principales:	Guisso, Dikran Richard, Saadeh, Fadi S., Saab, Dahlia, El Deek, Joud, Chamseddine, Sarah, El Hassan, Hadi Abou, Majari, Ghidaa, Boustany, Rose-Mary
Formato:	research tables/charts Journal Article
Publicado:	Springer Nature Jun2018
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2.9 [1.5-5.5], 2.1 [1.1-3.9]); consanguinity (2.5 [1.0-6.0]); family history of psychiatric disorders (2.2 [1.1-4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28-0.95]) and maternal psychological support during pregnancy (0.49 [0.27-0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention.