Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions.

Background: Psychiatric medications are widely prescribed in the USA. Many antipsychotics cause serum hyperprolactinemia as an adverse side effect; prolactin-Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling both induces cell differentiation and suppresses ap...

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Publicado en:	Breast Cancer Research Vol. 20; no. 1
Autores principales:	Johnston, A. N., Bu, W., Hein, S., Garcia, S., Camacho, L., Xue, L., Qin, L., Nagi, C., Hilsenbeck, S. G., Kapali, J., Podsypanina, K., Nangia, J., Li, Y.
Formato:	research Journal Article
Publicado:	BioMed Central 5/19/2018
Acceso en línea:	Ver este registro en EBSCOhost