Assessment of the equivalent dipole layer source model in the reconstruction of cardiac activation times on the basis of BSPMs produced by an anisotropic model of the heart.
Promising results have been reported in noninvasive estimation of cardiac activation times (AT) using the equivalent dipole layer (EDL) source model in combination with the boundary element method (BEM). However, the assumption of equal anisotropy ratios in the heart that underlies the EDL model doe...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 56; no. 6; pp. 1013 - 1026 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129738983&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129738983 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jun2018 vid: 56 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129738983 129738983 NLM29130137 129738983 10.1007/s11517-017-1715-x NLM29724520 129738983 ppf: 1013 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Assessment of the equivalent dipole layer source model in the reconstruction of cardiac activation times on the basis of BSPMs produced by an anisotropic model of the heart. aug: au: Janssen, Arno M. Potyagaylo, Danila Dössel, Olaf Oostendorp, Thom F. affil: The Netherlands Heart Institute, Utrecht, The Netherlands sug: subj: Neuroendocrine Tumors Radiotherapy Neuroendocrine Tumors Pathology Liver Neoplasms Liver Neoplasms Radiotherapy Embolization, Therapeutic Methods Radioisotopes Aged, 80 and Over Male Retrospective Design Latex Middle Age Survival Female Radiography, Interventional Adult Treatment Outcomes Aged Human Aged, 80 & over Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Promising results have been reported in noninvasive estimation of cardiac activation times (AT) using the equivalent dipole layer (EDL) source model in combination with the boundary element method (BEM). However, the assumption of equal anisotropy ratios in the heart that underlies the EDL model does not reflect reality. In the present study, we quantify the errors of the nonlinear AT imaging based on the EDL approximation. Nine different excitation patterns (sinus rhythm and eight ectopic beats) were simulated with the monodomain model. Based on the bidomain theory, the body surface potential maps (BSPMs) were calculated for a realistic finite element volume conductor with an anisotropic heart model. For the forward calculations, three cases of bidomain conductivity tensors in the heart were considered: isotropic, equal, and unequal anisotropy ratios in the intra- and extracellular spaces. In all inverse reconstructions, the EDL model with BEM was employed: AT were estimated by solving the nonlinear optimization problem with the initial guess provided by the fastest route algorithm. Expectedly, the case of unequal anisotropy ratios resulted in larger localization errors for almost all considered activation patterns. For the sinus rhythm, all sites of early activation were correctly estimated with an optimal regularization parameter being used. For the ectopic beats, all but one foci were correctly classified to have either endo- or epicardial origin with an average localization error of 20.4 mm for unequal anisotropy ratio. The obtained results confirm validation studies and suggest that cardiac anisotropy might be neglected in clinical applications of the considered EDL-based inverse procedure. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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