Diagnosis and Treatment of Human Salmonellosis in Addis Ababa City, Ethiopia.
Background. Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology. A cross-sectional study was conducted to assess the practice of diagnosis and treatment of salmo...
| Publicado en: | BioMed Research International Vol. 2018; pp. 1 - 8 |
|---|---|
| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
5/23/2018
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129742594&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129742594 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 5/23/2018 vid: 2018 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 129742594 129742594 129742594 10.1155/2018/6406405 129742594 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diagnosis and Treatment of Human Salmonellosis in Addis Ababa City, Ethiopia. aug: au: Garedew, Legesse Solomon, Semaria Worku, Yoseph Worku, Hilina Gemeda, Debela Lelissa, Gada Mamuye, Yeshwondm Abubeker, Rajiha Mihret, Amete Fentaw, Surafel Worku, Abeibe Bahiru, Melish Erenso, Girume affil: St Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia sug: subj: Salmonella Infections Diagnosis Salmonella Infections Drug Therapy Salmonella Infections Blood Feces Analysis Blood Culture Methods Fermentation Carbohydrate Metabolism Serotyping Microbial Culture and Sensitivity Tests Human Ethiopia Cross Sectional Studies Antigens Blood Sensitivity and Specificity Predictive Value of Tests Disease Susceptibility Ciprofloxacin Therapeutic Use Ceftriaxone Therapeutic Use Ampicillin Therapeutic Use Drug Resistance, Microbial Diagnostic Errors Salmonella Infections Symptoms Medication Errors ab: Background. Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology. A cross-sectional study was conducted to assess the practice of diagnosis and treatment of salmonellosis in Addis Ababa. Tube Widal test (for blood samples only), culture, biochemical and carbohydrate fermentation, serotyping, and antimicrobial susceptibility tests were employed for both blood and stool samples. Results. Of all the diseases listed in the diagnosis, nontyphoidal (n=72, 13.71%) and typhoidal (n=47, 8.95%) salmonellosis were the second and third common diseases. Among the 288 blood samples, almost half were positive for O, H, or both antigens. However, only 1 (0.68%) of the positive blood samples yielded Salmonella isolate during culture. The study demonstrated low specificity (0.68%) and positive predictive value (48.78%) of Widal test. Conversely, the test showed 100% sensitivity and negative predictive values. Salmonella isolates were identified from 7 (7.07%) of 99 stool samples. Two-thirds of salmonellosis suspected patients received antibiotic treatment. However, only half of the confirmed salmonellosis patients were treated with appropriate antibiotics. All of the isolates were susceptible to ciprofloxacin and ceftriaxone but resistant to ampicillin. Conclusions. Majority of the patients who participated in this study were wrongly diagnosed using symptoms, clinical signs, and tube Widal test. Consequently, most of the patients received inappropriate treatment. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|