Anti-Helicobacter pylori metabolites from Heterotheca inuloides (Mexican arnica).
Preparations of the plant known as “Mexican arnica” ( Heterotheca inuloides ) have been traditionally used for the treatment of several ailments including stomach ulcers and for relief of colic. To find possible biologically active components against these ailments, we tested the acetone extract as...
| Publicado en: | Fitoterapia Vol. 127; pp. 314 - 322 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129847204&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129847204 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Jun2018 vid: 127 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 129847204 129847204 129847204 10.1016/j.fitote.2018.03.001 129847204 ppf: 314 ppct: 8 formats: tig: atl: Anti-Helicobacter pylori metabolites from Heterotheca inuloides (Mexican arnica). aug: au: Egas, Verónica Salazar-Cervantes, Gabriela Romero, Irma Méndez-Cuesta, Carlos A. Rodríguez-Chávez, José Luis Delgado, Guillermo affil: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Mexico City, Mexico sug: subj: Plant Extracts Pharmacodynamics Helicobacter Infections Drug Therapy Helicobacter Pylori Terpenes Treatment Outcomes Spectrum Analysis Phytosterols ab: Preparations of the plant known as “Mexican arnica” ( Heterotheca inuloides ) have been traditionally used for the treatment of several ailments including stomach ulcers and for relief of colic. To find possible biologically active components against these ailments, we tested the acetone extract as well as different metabolites biosynthesized by this species, including cadinane-type sesquiterpenoids, triterpenes, phytosterols and flavonoids, against Helicobacter pylori . Among these compounds, sesquiterpenes 7-hydroxy-3,4-dihydrocadalene ( 3 ) and 7-hydroxy-cadalene ( 4 ) exhibited strong anti- H. pylori activity with MICs values of 1.95 and 3.91 μg/mL, respectively. HPLC-UV/DAD analyses revealed that both substances together with related compounds 7 , 8 and 9 were the major constituents of the acetone extract. Enzymatic assays and docking studies showed that unlike quercetin ( 10 ), a secondary metabolite also isolated from this species, compounds 3 and 4 did not inhibit the activity of urease, a potent virulence factor of H. pylori . Additionally, two new C 1 -C 9 secocadinanes ( 1 and 2 ) were isolated from the aerial parts of this species. Their structures were determined by extensive NMR and HRESIMS spectroscopic data analyses. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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