Prevalence of asymptomatic sexually transmitted infections in HIV-positive men who have sex with men in Germany: results of a multicentre cross-sectional study.
Purpose: Sexually transmitted infections (STIs) occur frequently in risk populations. Hereby, the role of screening-programmes remains controversial. Our study aimed to determine the prevalence of STI infections in HIV-positive men-who-have-sex-with-men (MSM).Methods: We enrolled asymptomatic, HIV-M...
| Publicado en: | Infection Vol. 46; no. 3; pp. 341 - 348 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=129889951&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 129889951 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Jun2018 vid: 46 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 129889951 129889951 129889951 10.1007/s15010-018-1124-6 129889951 ppf: 341 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prevalence of asymptomatic sexually transmitted infections in HIV-positive men who have sex with men in Germany: results of a multicentre cross-sectional study. aug: au: Spinner, Christoph D. Boesecke, Christoph Jordan, Cornelius Wyen, Christoph Kümmerle, Tim Knecht, Gaby Scholten, Stefan Zink, Alexander Krznaric, Ivanka Noe, Sebastian affil: Department of Medicine II, University Hospital Klinikum rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany sug: subj: Sexually Transmitted Diseases Epidemiology HIV-Positive Persons Men Who Have Sex With Men Germany Cross Sectional Studies Prospective Studies Neisseria Infections Adult Middle Age Syphilis Chlamydia Infections Substance Abuse Nitrites Unsafe Sex Multivariate Analysis Odds Ratio Treponemal Infections Hepatitis B Hepatitis C Questionnaires Male Multicenter Studies Disease Duration Gonorrhea Human Adult: 19-44 years Middle Aged: 45-64 years Male ab: Purpose: Sexually transmitted infections (STIs) occur frequently in risk populations. Hereby, the role of screening-programmes remains controversial. Our study aimed to determine the prevalence of STI infections in HIV-positive men-who-have-sex-with-men (MSM).Methods: We enrolled asymptomatic, HIV-MSM in a prospective cross-sectional study from February to August 2016 at seven German HIV-centres. All subjects were screened for Treponema-pallidum (TP) and hepatitis-B/C-infection. HIV RNA and screening for oral, rectal and urethral colonisation by Chlamydia-trachomatis (CT) and/or Neisseria-gonorrhoeae (NG) was performed. All subjects were asked to complete a sexual-risk-behaviour-questionnaire.Results: In total, 296 subjects with a median age of 43.2 (36.2-49.5) years were enrolled; 99.3% were on ART for 5.5 (2.3-11.2) years. HIV RNA was < 50 copies/mL in 93.6%. Active syphilis infection was found in 5.0% of all patients, whereas 55.4% had history of infection. HCV seropositivity was found in 33 patients (13.2%) and positive HCV RNA was available in 39.4%. 66/294 (22.5%) showed negative anti-HBs-antibodies, indicating lack of immunity. Overall, 40/296 (13.5%) had positive CT/NG swabs (CT in 8.8%; 7.3% anorectal, 1.7% oropharyngeal, 1.0% urethral and NG in 6.8%; 4.5% anal, 2.0% oropharyngeal, 1.4% urethral). Time since HIV infection < 7 years (OR 2.6 (1.2-5.5); p = 0.012), the use of inhalative nitrites (“poppers”) (OR 2.8 (1.3-5.9; p = 0.008) and reporting unprotected intercourse with > 20 partners within the last 6 months [OR 3.0 (1.2-7.8); p = 0.003] were significantly associated in multivariate analysis.Conclusion: We found high numbers of asymptomatic syphilis, hepatitis-C and CT/NG infections in HIV-MSM, remarkably in patients with shorter duration of HIV-infection with more sexual partners within last 6 months. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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